ZFIN ID: ZDB-FIG-140422-51
Sfrp1a/5 loss of function does not affect nasal-temporal retinal patterning. Having observed alterations in dorso-ventral patterning in sfrp1a/5 morpholino (MO) injected embryos, we sought to analyze naso-temporal pattering by performing in situ hybridization for temporal (foxd1) and nasal (foxg1a) retina markers. Compared to WT, sfrp1a/5 MO injected embryos display no change in the expression pattern of foxg1a (A-B) (n=17/17) or foxd1 (C-D) (n=14/14) at 28 hpf.
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Reprinted from Developmental Biology, 388(2), Holly, V.L., Widen, S.A., Famulski, J.K., and Waskiewicz, A.J., Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development, 192-204, Copyright
(2014) with permission from Elsevier.
Full text @ Dev. Biol.