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ZIRC
ZFIN ID: ZDB-FIG-120601-51
Chu et al., 2012 - Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One   7(5):e36474 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 5 Histology of the obese transformed Tg (krt4:Hsa.myrAkt1)cy18.

(A) Schematic diagram showing the relative positions (red dotted boxes) for histological sections from B to I. Histological assessment of dorsal muscle tissues (B and C), visceral adipocytes (D and E), gill arch (F and G) and bone tissues in the tail (H and I) for WT and Tg aged 3 mpf. The paraffin sections in B to G were stained with Periodic acid-Schiff, and bone tissues in the tail regions (H&I) were stained with Masson’s trichrome. Comparison adipocyte average size (J), adipocyte numbers (K), and adipocyte size distribution histogram (L) between WT and Tg. Stars above the error bars indicate significant differences as tested by Student’s t-test (*p<0.05, **p<0.01, and ***p<0.001). WT, wild type; Tg, Tg(krt4:Hsa.myrAkt1)cy18; mpf, month post-fertilization.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
cy18Tg standard conditions Adult fat cell located in pharyngeal arch 3-7, abnormal
Adult fat cell located in trunk musculature, abnormal
Adult fat cell located in vertebral column, abnormal
Adult hypodermis adipose tissue mislocalised, abnormal
Adult pharyngeal arch adipose tissue mislocalised, abnormal
Adult pleuroperitoneal cavity fat cell increased amount, abnormal
Adult pleuroperitoneal cavity fat cell size, normal
Adult trunk musculature adipose tissue mislocalised, abnormal
Adult vertebral column adipose tissue mislocalised, abnormal
Acknowledgments:
ZFIN wishes to thank the journal PLoS One for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS One