Gene
mpx
- ID
- ZDB-GENE-030131-9460
- Name
- myeloid-specific peroxidase
- Symbol
- mpx Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables peroxidase activity. Acts upstream of or within inflammatory response; regulation of hydrogen peroxide metabolic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including EPX (eosinophil peroxidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 355 figures from 242 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1013 (3 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| gl8 | Allele with one point mutation | Unknown | Unknown | not specified | |
| ihb892Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa18566 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21652 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34835 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sm681 | Allele with one deletion | Exon 13 | Premature Stop | ENU | |
| t30963 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mpx | Isles et al., 2021 | |
| CRISPR2-mpx | Wang et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001073 | C1q domain |
| Family | IPR019791 | Haem peroxidase, animal-type |
| Homologous_superfamily | IPR008983 | Tumour necrosis factor-like domain superfamily |
| Homologous_superfamily | IPR010255 | Haem peroxidase superfamily |
| Homologous_superfamily | IPR037120 | Haem peroxidase domain superfamily, animal type |
Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q5S9 | InterPro | 892 | |||||
| UniProtKB:A0A8M1P4H4 | InterPro | 893 | |||||
| UniProtKB:Q90XS6 | InterPro | 762 | |||||
| UniProtKB:F1Q944 | InterPro | 762 |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(-8mpx:cxcr4b-EGFP) |
|
| 1 | (10) | |
| Tg(mpx:GFP) |
|
| 3 | (494) | |
| Tg2(mpx:EGFP) |
|
| 1 | Ear et al., 2015 | |
| Tg3(mpx:EGFP) |
|
| 1 | Ku et al., 2018 | |
| Tg4(mpx:EGFP) |
|
| 1 | Reinhardt et al., 2019 | |
| Tg5(mpx:EGFP) |
|
| 1 | Yuan et al., 2020 | |
| Tg6(mpx:EGFP) |
|
| 1 | Zhang et al., 2020 | |
| Tg(-8mpx:cxcr4b-EGFP) |
|
| 1 | (2) | |
| Tg(-8mpx:EGFP-CAAX) |
|
| 1 | (4) | |
| Tg(-8mpx:H2B-Cerulean-2A-mKOFP2-CAAX) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-340N8 | ZFIN Curated Data | |
| Encodes | EST | cb1013 | ||
| Encodes | EST | fj80f04 | ||
| Encodes | cDNA | MGC:65945 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85760 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212779 (1) | 3205 nt | ||
| Genomic | GenBank:CU681843 (2) | 72220 nt | ||
| Polypeptide | UniProtKB:A0A8M1P4H4 (1) | 893 aa |
No data available
- Belt, A.J., Grant, S., Tombes, R.M., Rothschild, S.C. (2024) Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos. PLoS Genetics. 20:e1011308e1011308
- Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Isiaku, A.I., Zhang, Z., Pazhakh, V., Lieschke, G.J. (2024) A nox2/cybb zebrafish mutant with defective myeloid cell reactive oxygen species production displays normal initial neutrophil recruitment to sterile tail injuries. G3 (Bethesda). 14(6):
- Ketharnathan, S., Pokharel, S., Prykhozhij, S.V., Cordeiro-Santanach, A., Ban, K., Dogan, S., Hoang, H.D., Liebman, M.F., Leung, E., Alain, T., Alecu, I., Bennett, S.A.L., Čuperlović-Culf, M., Dror, Y., Berman, J.N. (2024) Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish. Leukemia. 38(10):2115-2126
- Lee, S., Ye, Q., Yang, H., Lee, S., Kim, Y., Lee, N., Gonzalez-Cox, D., Yi, D.K., Kim, S.Y., Choi, S., Choi, T., Kim, M.S., Hong, S.S., Choi, C.W., Lee, Y., Park, Y.H. (2024) Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3. Scientific Reports. 14:52375237
- Liang, H., Li, M., Chen, J., Zhou, W., Xia, D., Ding, Q., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2024) The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish. Microbiome. 12:244244
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
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