Gene
mpx
- ID
- ZDB-GENE-030131-9460
- Name
- myeloid-specific peroxidase
- Symbol
- mpx Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables peroxidase activity. Acts upstream of or within inflammatory response; regulation of hydrogen peroxide metabolic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including digestive system; hematopoietic cell; hematopoietic system; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including EPX (eosinophil peroxidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 356 figures from 243 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1013 (3 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001073 | C1q domain |
| Family | IPR019791 | Haem peroxidase, animal-type |
| Homologous_superfamily | IPR008983 | Tumour necrosis factor-like domain superfamily |
| Homologous_superfamily | IPR010255 | Haem peroxidase superfamily |
| Homologous_superfamily | IPR037120 | Haem peroxidase domain superfamily, animal type |
Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q5S9 | InterPro | 892 | |||||
| UniProtKB:A0A8M1P4H4 | InterPro | 893 | |||||
| UniProtKB:Q90XS6 | InterPro | 762 | |||||
| UniProtKB:F1Q944 | InterPro | 762 |
Interactions and Pathways
No data available
Plasmids