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Gene

cxcr4b

ID
ZDB-GENE-010614-1
Name
chemokine (C-X-C motif), receptor 4b
Symbol
cxcr4b Nomenclature History
Previous Names
  • drCXCR4b1 (1)
  • cb403 (1)
  • ody
  • odysseus
  • zgc:109863
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Enables G protein-coupled chemoattractant receptor activity. Acts upstream of or within several processes, including gamete generation; nervous system development; and regulation of chemotaxis. Located in plasma membrane. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neurogenic placode. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
109 figures from 78 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 18 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcr4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
WHIM syndrome Alliance Myelokathexis, isolated 193670
WHIM syndrome Alliance WHIM syndrome 1 193670
Associated With cxcr4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000355 Chemokine receptor family
Family IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2
Domain Details Per Protein
Protein Length Chemokine receptor family CXC chemokine receptor 4/atypical chemokine receptor 2 GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q504H4 353
UniProtKB:Q9PTF7 353
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cxcr4b monoclonal Mouse
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations