ZFIN

ZFIN ID: ZDB-GENE-060328-3

ZFIN ID: ZDB-GENE-060328-3

CITATIONS (70 total)

Gene Name:	wingless-type MMTV integration site family, member 5a
Gene Symbol:	wnt5a

Dennhag, N., Kahsay, A., Nissen, I., Nord, H., Chermenina, M., Liu, J., Arner, A., Liu, J.X., Backman, L.J., Remeseiro, S., von Hofsten, J., Pedrosa Domellöf, F. (2024) fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Nature communications. 15:19501950

Raterman, S.T., Von Den Hoff, J.W., Dijkstra, S., De Vriend, C., Te Morsche, T., Broekman, S., Zethof, J., De Vrieze, E., Wagener, F.A.D.T.G., Metz, J.R. (2023) Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid. Frontiers in cell and developmental biology. 11:11438441143844

Naraine, R., Iegorova, V., Abaffy, P., Franek, R., Soukup, V., Psenicka, M., Sindelka, R. (2022) Evolutionary conservation of maternal RNA localization in fishes and amphibians revealed by TOMO-Seq. Developmental Biology. 489:146-160

Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39

Cao, Z., Meng, Y., Gong, F., Xu, Z., Liu, F., Fang, M., Zou, L., Liao, X., Wang, X., Luo, L., Li, X., Lu, H. (2021) Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration. Proceedings of the National Academy of Sciences of the United States of America. 118(2):

Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X., Wang, S., Xu, S., Zheng, M., Huang, J., Wan, X., Guan, W., Su, K.P., Ye, M., Gao, X., Yin, Z., Li, X. (2021) Ghrelin Modulates Dopaminergic Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models. Brain, behavior, and immunity. 94:327-337

Stewart, S., Le Bleu, H.K., Yette, G.A., Henner, A.L., Robbins, A.E., Braunstein, J.A., Stankunas, K. (2021) longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth. Development (Cambridge, England). 148(11):

Castanon, I., Hannich, J.T., Abrami, L., Huber, F., Dubois, M., Müller, M., van der Goot, F.G., Gonzalez-Gaitan, M. (2020) Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish. Nature communications. 11:3317

Gu, L., Tian, L., Gao, G., Peng, S., Zhang, J., Wu, D., Huang, J., Hua, Q., Lu, T., Zhong, L., Fu, Z., Pan, X., Qian, H., Sun, L. (2020) Inhibitory effects of polystyrene microplastics on caudal fin regeneration in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 266:114664

Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264

Crespo, D., Lemos, M.S., Zhang, Y.T., Safian, D., Norberg, B., Bogerd, J., Schulz, R. (2019) PGE2 inhibits spermatogonia differentiation in zebrafish: interaction with Fsh and an androgen. The Journal of endocrinology. 244(1):163-175

Wang, S., Duan, M., Guan, K., Zhou, X., Zheng, M., Shi, X., Ye, M., Guan, W., Kuver, A., Huang, M., Liu, Y., Dai, K., Li, X. (2019) Developmental neurotoxicity of reserpine exposure in zebrafish larvae (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 223:115-123

Bai, Y., Liu, C., Zhou, J., Rong, X., Wang, H. (2018) Molecular, functional, and gene expression analysis of zebrafish Ror1 receptor. Fish physiology and biochemistry. 45(1):355-363

Safian, D., Ryane, N., Bogerd, J., Schulz, R.W. (2018) Fsh stimulates Leydig cell Wnt5a production, enriching zebrafish type A spermatogonia. The Journal of endocrinology. 239:351-363

Si, J., Zhou, R., Zhao, B., Xie, Y., Gan, L., Zhang, J., Wang, Y., Zhou, X., Ren, X., Zhang, H. (2018) Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity. Toxicology. 411:143-153

Matsukawa, T., Morita, K., Omizu, S., Kato, S., Koriyama, Y. (2017) Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration. Neurochemistry international. 112:71-80

Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726

Schall, K.A., Thornton, M.E., Isani, M., Holoyda, K.A., Hou, X., Lien, C.L., Grubbs, B.H., Grikscheit, T.C. (2017) Short bowel syndrome results in increased gene expression associated with proliferation, inflammation, bile acid synthesis and immune system activation: RNA sequencing a zebrafish SBS model. BMC Genomics. 18:23

Grainger, S., Richter, J., Palazón, R.E., Pouget, C., Lonquich, B., Wirth, S., Grassme, K.S., Herzog, W., Swift, M.R., Weinstein, B.M., Traver, D., Willert, K. (2016) Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Reports. 17:1595-1606

Hofsteen, P., Robitaille, A.M., Chapman, D.P., Moon, R.T., Murry, C.E. (2016) Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling. Proceedings of the National Academy of Sciences of the United States of America. 113(4):1002-7

Yang, Q., Chen, D., Xiong, F., Chen, D., Liu, C., Liu, Y., Yu, Q., Xiong, J., Liu, J., Li, K., Zhao, L., Ye, Y., Zhou, H., Hu, L., Tian, Z., Shang, X., Zhang, L., Wei, X., Zhou, W., Li, D., Zhang, W., Xu, X. (2016) A splicing mutation in VPS4B causes dentin dysplasia I. Journal of Medical Genetics. 53(9):624-33

Duncan, R.N., Panahi, S., Piotrowski, T., Dorsky, R.I. (2015) Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development. PLoS One. 10:e0145810

Huang, J., Zhong, Z., Wang, M., Chen, X., Tan, Y., Zhang, S., He, W., He, X., Huang, G., Lu, H., Wu, P., Che, Y., Yan, Y.L., Postlethwait, J.H., Chen, W., Wang, H. (2015) Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:2572-87

Huang, L., Xiao, A., Choi, S.Y., Kan, Q., Zhou, W., Chacon-Heszele, M.F., Ryu, Y.K., McKenna, S., Zuo, X., Kuruvilla, R., Lipschutz, J.H. (2014) Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice. Nephron. Experimental nephrology. 128(1-2):80-8

Huang, L., Xiao, A., Wecker, A., McBride, D.A., Choi, S.Y., Zhou, W., Lipschutz, J.H. (2014) A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys. Journal of visualized experiments : JoVE. (94)

Ju, B., Chen, W., Spitsbergen, J.M., Lu, J., Vogel, P., Peters, J.L., Wang, Y.D., Orr, B.A., Wu, J., Henson, H.E., Jia, S., Parupalli, C., Taylor, M.R. (2014) Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway. Oncogenesis. 3:e96

Kujawski, S., Lin, W., Kitte, F., Börmel, M., Fuchs, S., Arulmozhivarman, G., Vogt, S., Theil, D., Zhang, Y., Antos, C.L. (2014) Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Developmental Cell. 28:573-87

Li, M., Wang, X., Zhu, J., Zhu, S., Hu, X., Zhu, C., Guo, X., Yu, Z., Han, S. (2014) Toxic effects of polychlorinated biphenyls on cardiac development in zebrafish. Molecular biology reports. 41(12):7973-83

Stewart, S., Gomez, A.W., Armstrong, B.E., Henner, A., and Stankunas, K. (2014) Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration. Cell Reports. 6(3):482-498

Castanon, I., Abrami, L., Holtzer, L., Heisenberg, C.P., van der Goot, F.G., and González-Gaitán, M. (2013) Anthrax toxin receptor 2a controls mitotic spindle positioning. Nature cell biology. 15(1):28-39

Liu, Y.Q., Song, G.X., Liu, H.L., Wang, X.J., Shen, Y.H., Zhou, L.J., Jin, J., Liu, M., Shi, C.M., and Qian, L.M. (2013) Silencing of FABP3 leads to apoptosis-induced mitochondrial dysfunction and stimulates Wnt signaling in zebrafish. Molecular Medicine Reports. 8(3):806-12

Ye, Z., Zhang, C., Tu, T., Sun, M., Liu, D., Lu, D., Feng, J., Yang, D., Liu, F., and Yan, X. (2013) Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nature communications. 4:2803

Louwette, S., Labarque, V., Wittevrongel, C., Thys, C., Metz, J., Gijsbers, R., Debyser, Z., Arnout, J., Van Geet, C., and Freson, K. (2012) Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(5):2125-2136

Yuan, Q., Chiquet, B.T., Devault, L., Warman, M.L., Nakamura, Y., Swindell, E.C., and Hecht, J.T. (2012) Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish. Genesis (New York, N.Y. : 2000). 50(12):871-881

Lu, F.I., Thisse, C., and Thisse, B. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant. Proceedings of the National Academy of Sciences of the United States of America. 108(38):15876-80

Ramachandran, R., Zhao, X.F., and Goldman, D. (2011) Ascl1a/Dkk/ beta -catenin signaling pathway is necessary and glycogen synthase kinase-3 beta inhibition is sufficient for zebrafish retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 108(38):15858-63

Nojima, H., Rothhämel, S., Shimizu, T., Kim, C.H., Yonemura, S., Marlow, F.L., and Hibi, M. (2010) Syntabulin, a motor protein linker, controls dorsal determination. Development (Cambridge, England). 137(6):923-933

Rhodes, J.M., Bentley, F.K., Print, C.G., Dorsett, D., Misulovin, Z., Dickinson, E.J., Crosier, K.E., Crosier, P.S., and Horsfield, J.A. (2010) Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology. 344(2):637-649

Chen, Y.H., Wang, Y.H., Yu, T.H., Wu, H.J., and Pai, C.W. (2009) Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds. Transgenic Research. 18(6):855-864

Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C. (2009) ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. Developmental Biology. 327(1):177-190

Garriock, R.J., Warkman, A.S., Meadows, S.M., D'Agostino, S., and Krieg, P.A. (2007) Census of vertebrate Wnt genes: Isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(5):1249-1258

Nambiar, R.M., Ignatius, M.S., and Henion, P.D. (2007) Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration. Mechanisms of Development. 124(9-10):682-698

Stoick-Cooper, C.L., Weidinger, G., Riehle, K.J., Hubbert, C., Major, M.B., Fausto N., and Moon, R.T. (2007) Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development (Cambridge, England). 134(3):479-489

Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L. (2006) Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(6):1578-1588

Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (24):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

ZIRC and ZFIN staff (2011) Mutant and Transgenic Line Submissions 2011. ZFIN Direct Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

ZF-MODELS Consortium (2007) ZF-MODELS Consortium and Zebrafish Mutation Resource targeted knock-out mutants. ZFIN Direct Data Submission.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.