PUBLICATION
Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd
- Authors
- Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L.
- ID
- ZDB-PUB-060323-33
- Date
- 2006
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 235(6): 1578-1588 (Journal)
- Registered Authors
- Allende, Miguel L., Ghysen, Alain, Renucci, Armand, Sapede, Dora, Soubiran, Fabien
- Keywords
- lateral line, morpholino, 4-Di-2-ASP, cell migration, EpCAM, trop2
- MeSH Terms
-
- Amino Acid Sequence
- Humans
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- Zebrafish Proteins/physiology
- Calcium Signaling/genetics*
- Calcium Signaling/physiology
- Zebrafish/embryology*
- Membrane Glycoproteins/genetics*
- Membrane Glycoproteins/metabolism
- Animals
- Antigens, Neoplasm/genetics
- Cell Movement/genetics*
- Cell Movement/physiology
- Molecular Sequence Data
- Cell Adhesion Molecules/genetics
- PubMed
- 16552761 Full text @ Dev. Dyn.
Citation
Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L. (2006) Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(6):1578-1588.
Abstract
The sensory organs of the zebrafish lateral-line system (neuromasts) originate from migrating primordia that move along precise pathways. The posterior primordium, which deposits the neuromasts on the body and tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail. This migration is controlled by the chemokine SDF1, which is expressed along the prospective pathway, and by its receptor CXCR4, which is expressed by the migrating cells. In this report, we describe another zebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for a membrane protein that is homologous to the TACSTD1/2 mammalian proteins. Inactivation of the zebrafish tacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for the deposition process.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping