PUBLICATION

Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd

Authors
Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L.
ID
ZDB-PUB-060323-33
Date
2006
Source
Developmental dynamics : an official publication of the American Association of Anatomists   235(6): 1578-1588 (Journal)
Registered Authors
Allende, Miguel L., Ghysen, Alain, Renucci, Armand, Sapede, Dora, Soubiran, Fabien
Keywords
lateral line, morpholino, 4-Di-2-ASP, cell migration, EpCAM, trop2
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Antigens, Neoplasm/genetics
  • Calcium Signaling/genetics*
  • Calcium Signaling/physiology
  • Cell Adhesion Molecules/genetics
  • Cell Movement/genetics*
  • Cell Movement/physiology
  • Humans
  • Membrane Glycoproteins/genetics*
  • Membrane Glycoproteins/metabolism
  • Molecular Sequence Data
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology
PubMed
16552761 Full text @ Dev. Dyn.
Abstract
The sensory organs of the zebrafish lateral-line system (neuromasts) originate from migrating primordia that move along precise pathways. The posterior primordium, which deposits the neuromasts on the body and tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail. This migration is controlled by the chemokine SDF1, which is expressed along the prospective pathway, and by its receptor CXCR4, which is expressed by the migrating cells. In this report, we describe another zebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for a membrane protein that is homologous to the TACSTD1/2 mammalian proteins. Inactivation of the zebrafish tacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for the deposition process.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes