ZFIN

ZFIN ID: ZDB-GENE-030616-115

ZFIN ID: ZDB-GENE-030616-115

CITATIONS (67 total)

Gene Name:	leukocyte receptor tyrosine kinase
Gene Symbol:	ltk

Eom, D.S., Patterson, L.B., Bostic, R.R., Parichy, D.M. (2021) Immunoglobulin superfamily receptor junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes. Developmental Biology. 476:314-327

McCluskey, B.M., Liang, Y., Lewis, V.M., Patterson, L.B., Parichy, D.M. (2021) Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects. Biology Open. 10(9):

McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364

Petratou, K., Spencer, S.A., Kelsh, R.N., Lister, J.A. (2021) The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor. PLoS One. 16:e0244794

McGuirl, M.R., Volkening, A., Sandstede, B. (2020) Topological data analysis of zebrafish patterns. Proceedings of the National Academy of Sciences of the United States of America. 117(10):5113-5124

Volkening, A., Abbott, M.R., Chandra, N., Dubois, B., Lim, F., Sexton, D., Sandstede, B. (2020) Modeling Stripe Formation on Growing Zebrafish Tailfins. Bulletin of mathematical biology. 82:56

Camargo-Sosa, K., Colanesi, S., Müller, J., Schulte-Merker, S., Stemple, D., Patton, E.E., Kelsh, R.N. (2019) Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish. PLoS Genetics. 15:e1007941

Eskova, A., Frohnhöfer, H.G., Nüsslein-Volhard, C., Irion, U. (2019) Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish. Current biology : CB. 30(2):298-303.e3

Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811

Fadeev, A., Mendoza-Garcia, P., Irion, U., Guan, J., Pfeifer, K., Wiessner, S., Serluca, F., Singh, A.P., Nüsslein-Volhard, C., Palmer, R.H. (2018) ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells. Proceedings of the National Academy of Sciences of the United States of America. 115(4):E630-E638

Hozumi, S., Shirai, M., Wang, J., Aoki, S., Kikuchi, Y. (2018) The N-terminal domain of gastrulation brain homeobox 2 (Gbx2) is required for iridophore specification in zebrafish. Biochemical and Biophysical Research Communications. 502(1):104-109

Petratou, K., Subkhankulova, T., Lister, J.A., Rocco, A., Schwetlick, H., Kelsh, R.N. (2018) A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest. PLoS Genetics. 14:e1007402

Spiewak, J.E., Bain, E.J., Liu, J., Kou, K., Sturiale, S.L., Patterson, L.B., Diba, P., Eisen, J.S., Braasch, I., Ganz, J., Parichy, D.M. (2018) Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes. PLoS Genetics. 14:e1007538

Volkening, A., Sandstede, B. (2018) Iridophores as a source of robustness in zebrafish stripes and variability in Danio patterns. Nature communications. 9:3231

Heffer, A., Marquart, G.D., Aquilina-Beck, A., Saleem, N., Burgess, H.A., Dawid, I.B. (2017) Generation and characterization of Kctd15 mutations in zebrafish. PLoS One. 12:e0189162

Mo, E.S., Cheng, Q., Reshetnyak, A.V., Schlessinger, J., Nicoli, S. (2017) Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk. Proceedings of the National Academy of Sciences of the United States of America. 114(45):12027-12032

Fadeev, A., Krauss, J., Singh, A.P., Nüsslein-Volhard, C. (2016) Zebrafish leukocyte tyrosine kinase controls iridophore establishment, proliferation and survival. Pigment cell & melanoma research. 29(3):284-96

Mahalwar, P., Singh, A.P., Fadeev, A., Nüsslein-Volhard, C., Irion, U. (2016) Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish. Biology Open. 5(11):1680-1690

Singh, A.P., Dinwiddie, A., Mahalwar, P., Schach, U., Linker, C., Irion, U., Nüsslein-Volhard, C. (2016) Pigment Cell Progenitors in Zebrafish Remain Multipotent through Metamorphosis. Developmental Cell. 38(3):316-30

Walderich, B., Singh, A.P., Mahalwar, P., Nüsslein-Volhard, C. (2016) Homotypic cell competition regulates proliferation and tiling of zebrafish pigment cells during colour pattern formation. Nature communications. 7:11462

Ceinos, R.M., Guillot, R., Kelsh, R.N., Cerdá-Reverter, J.M., Rotllant, J. (2015) Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms. Pigment cell & melanoma research. 28(2):196-209

Eom, D.S., Bain, E.J., Patterson, L.B., Grout, M.E., Parichy, D.M. (2015) Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLIFE. 4

Fadeev, A., Krauss, J., Frohnhöfer, H.G., Irion, U., Nüsslein-Volhard, C. (2015) Tight junction protein 1a regulates pigment cell organisation during zebrafish colour patterning. eLIFE. 4

Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8

Irion, U., Frohnhöfer, H.G., Krauss, J., Çolak Champollion, T., Maischein, H., Geiger-Rudolph, S., Weiler, C., Nüsslein-Volhard, C. (2014) Gap junctions composed of connexions 41.8 and 39.4 are essential for colour pattern formation in zebrafish. eLIFE. 4:1225-38

Singh, A.P., Schach, U., Nüsslein-Volhard, C. (2014) Proliferation, dispersal and patterned aggregation of iridophores in the skin prefigure striped colouration of zebrafish. Nature cell biology. 16(6):607-14

Frohnhöfer, H.G., Krauss, J., Maischein, H.M., and Nüsslein-Volhard, C. (2013) Iridophores and their interactions with other chromatophores are required for stripe formation in zebrafish. Development (Cambridge, England). 140(14):2997-3007

Higdon, C.W., Mitra, R.D., and Johnson, S.L. (2013) Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS One. 8(7):e67801

Patterson, L.B., and Parichy, D.M. (2013) Interactions with Iridophores and the Tissue Environment Required for Patterning Melanophores and Xanthophores during Zebrafish Adult Pigment Stripe Formation. PLoS Genetics. 9(5):e1003561

Colanesi, S., Taylor, K.L., Temperley, N.D., Lundegaard, P.R., Liu, D., North, T.E., Ishizaki, H., Kelsh, R.N., and Patton, E.E. (2012) Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment cell & melanoma research. 25(2):131-143

Rodrigues, F.S., Yang, X., Nikaido, M., Liu, Q., and Kelsh, R.N. (2012) A Simple, Highly Visual in Vivo Screen for Anaplastic Lymphoma Kinase Inhibitors. ACS Chemical Biology. 7(12):1968-1974

Curran, K., Lister, J.A., Kunkel, G.R., Prendergast, A., Parichy, D.M., and Raible, D.W. (2010) Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Developmental Biology. 344(1):107-118

Arduini, B.L., Bosse, K.M., and Henion, P.D. (2009) Genetic ablation of neural crest cell diversification. Development (Cambridge, England). 136(12):1987-1994

Lang, M.R., Patterson, L.B., Gordon, T.N., Johnson, S.L., and Parichy, D.M. (2009) Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genetics. 5(11):e1000744

Lopes, S.S., Yang, X., Müller, J., Carney, T.J., McAdow, A.R., Rauch, G.J., Jacoby, A.S., Hurst, L.D., Delfino-Machín, M., Haffter, P., Geisler, R., Johnson, S.L., Ward, A., and Kelsh, R.N. (2008) Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genetics. 4(3):e1000026

Yang, C.T., and Johnson, S.L. (2006) Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes. Development (Cambridge, England). 133(18):3563-3573

Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466

Parichy, D.M., Mellgren, E.M., Rawls, J.F., Lopes, S.S., Kelsh, R.N., and Johnson, S.L. (2000) Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. Developmental Biology. 227(2):294-306

Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36

Haffter, P., Odenthal, J., Mullins, M.C., Lin, S., Farrell, M.J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F.J.M., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Hopkins, N., and Nüsslein-Volhard, C. (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Development genes and evolution. 206(4):260-276

Kelsh, R.N., Brand, M., Jiang, Y.J., Heisenberg, C.P., Lin, S., Haffter, P., Odenthal, J., Mullins, M.C., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Kane, D.A., Warga, R.M., Beuchle, D., Vogelsang, L., and Nüsslein-Volhard, C. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England). 123:369-389

Additional Citations (26):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Varshney, G.K., Zhang, S., Burgess, S.M., ZFIN Staff (2015) Automated Data Load From CRISPRz. ZFIN Direct Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

Geisler, R. (2013) Importation of Tübingen internal allele names. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZIRC and ZFIN staff (2010) Mutant and Transgenic Line Submissions 2010. ZFIN Direct Data Submission.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

Phenotype Annotation (1994-2006) (2006) Mutant Data Curated from Older Literature. ZFIN Historical Data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) Temporary Manual Curation. Manually curated data.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.