PUBLICATION

Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms

Authors
Ceinos, R.M., Guillot, R., Kelsh, R.N., Cerdá-Reverter, J.M., Rotllant, J.
ID
ZDB-PUB-141204-5
Date
2015
Source
Pigment cell & melanoma research   28(2): 196-209 (Journal)
Registered Authors
Cerdá-Reverter, José Miguel, Kelsh, Robert, Rotllant, Josep
Keywords
asip1, dct, ltk, mitfa, tyrp1b, xdh, Agouti, chromatophore, iridophore, melanocyte, melanophore, pigment pattern formation, transgenic, zebrafish
MeSH Terms
  • Animals
  • Cell Count
  • Gene Expression Regulation, Developmental
  • Larva/genetics
  • Melanophores/metabolism
  • Pigmentation*/genetics
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Time Factors
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed
25469713 Full text @ Pigment Cell Melanoma Res.
Abstract
Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, ASIP. In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms - an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern. This article is protected by copyright. All rights reserved.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes