ZFIN ID: ZDB-GENE-030616-115
Gene Name: leukocyte receptor tyrosine kinase
Gene Symbol: ltk    Nomenclature History

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Previous Names: shd(l), si:dz107o16.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including iridophore differentiation; melanocyte migration; and pigment cell development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including immature eye; iridoblast; neural crest; notochord; and pigment cell. Orthologous to several human genes including LTK (leukocyte receptor tyrosine kinase).
Genome Resources: Alliance (1),  Gene:564470 (1),  Ensembl(GRCz11):ENSDARG00000042861 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dtwc3 Point Mutation Unknown Missense ENU
j9e1 Point Mutation Unknown Unknown
j9e2 Point Mutation Unknown Unknown
j9s1 Point Mutation Unknown Missense SPONTANEOUS
sa1500 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9910 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42962 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45612 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc205 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te295 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te300 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf238c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th219 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ti263c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tj229e Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm46a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp218 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty9 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty70 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty82 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ya347 Small Deletion Unknown Unknown CRISPR
    DISEASE ASSOCIATED WITH ltk HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Neuroblastoma, susceptibility to, 3} 613014
    DISEASE ASSOCIATED WITH ltk VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ltk-201 (1)    Ensembl 4652
    ltk-202 (1)    Ensembl 4697
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ltk No data available
    MARKER RELATIONSHIPS
    ltk Contained in: [BAC] CH211-254C11 (1), DKEY-170L10 (1) (order this)
    [PAC] BUSM1-107O16 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001006660 (1) 4593 nt
    Genomic GenBank:AL596022 (1) 121941 nt
    Select Tool
    Polypeptide UniProtKB:B0LVZ8 (1) 1530 aa
    Sequence Information (all 31)
    ORTHOLOGY for ltk ( Chr: 17 )
    CITATIONS (58)