Gene

ltk

ID
ZDB-GENE-030616-115
Name
leukocyte receptor tyrosine kinase
Symbol
ltk Nomenclature History
Previous Names
  • shd(l)
  • si:dz107o16.1
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including iridophore differentiation; melanocyte migration; and pigment cell development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including immature eye; iridoblast; neural crest; notochord; and pigment cell. Orthologous to several human genes including LTK (leukocyte receptor tyrosine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
36 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ltk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Neuroblastoma, susceptibility to, 3} 613014
Associated With ltk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR000998 MAM domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR026984 Leukocyte tyrosine kinase receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily LDL receptor-like superfamily Leukocyte tyrosine kinase receptor Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat MAM domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:A0A2R8QED1 1500
UniProtKB:A0A0B5JW94 453
UniProtKB:F1QBU7 1504
UniProtKB:F1QVU0 1530
UniProtKB:B1PHI5 785
UniProtKB:A0A2R8QI76 1526
UniProtKB:Q8JFV0 1161
UniProtKB:B1PCZ3 1504
UniProtKB:B0LVZ8 1530
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations