PUBLICATION
Modeling Stripe Formation on Growing Zebrafish Tailfins
- Authors
- Volkening, A., Abbott, M.R., Chandra, N., Dubois, B., Lim, F., Sexton, D., Sandstede, B.
- ID
- ZDB-PUB-200502-4
- Date
- 2020
- Source
- Bulletin of mathematical biology 82: 56 (Journal)
- Registered Authors
- Keywords
- Agent-based model, Growing domain, Pattern formation, Self-organization, Tailfin, Zebrafish
- MeSH Terms
-
- Animal Fins/anatomy & histology
- Animal Fins/cytology
- Animal Fins/growth & development
- Animals
- Body Patterning/genetics
- Body Patterning/physiology
- Cell Communication/physiology
- Cell Differentiation/physiology
- Cell Movement/physiology
- Computer Simulation
- Epithelium/growth & development
- Mathematical Concepts
- Models, Biological*
- Mutation
- Skin Pigmentation/genetics
- Skin Pigmentation/physiology
- Systems Analysis
- Zebrafish/genetics
- Zebrafish/growth & development*
- Zebrafish/physiology
- PubMed
- 32356149 Full text @ Bull. Math. Biol.
Citation
Volkening, A., Abbott, M.R., Chandra, N., Dubois, B., Lim, F., Sexton, D., Sandstede, B. (2020) Modeling Stripe Formation on Growing Zebrafish Tailfins. Bulletin of mathematical biology. 82:56.
Abstract
As zebrafish develop, black and gold stripes form across their skin due to the interactions of brightly colored pigment cells. These characteristic patterns emerge on the growing fish body, as well as on the anal and caudal fins. While wild-type stripes form parallel to a horizontal marker on the body, patterns on the tailfin gradually extend distally outward. Interestingly, several mutations lead to altered body patterns without affecting fin stripes. Through an exploratory modeling approach, our goal is to help better understand these differences between body and fin patterns. By adapting a prior agent-based model of cell interactions on the fish body, we present an in silico study of stripe development on tailfins. Our main result is a demonstration that two cell types can produce stripes on the caudal fin. We highlight several ways that bone rays, growth, and the body-fin interface may be involved in patterning, and we raise questions for future work related to pattern robustness.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping