ZFIN Morpholino: MO1-gata4

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-gata4

Expressed Gene	Anatomy	Figures
cp	hepatocyte	Fig. 5 from Shin et al., 2007
cxcl12a	head mesoderm pronephric duct	Fig. 5 from Torregroza et al., 2012
dand5	Kupffer's vesicle	Fig. S4 from Lin et al., 2009
ela2l	(not) whole organism	Fig. 4 from Holtzinger et al., 2005
fabp2	(not) whole organism	Fig. 4 from Holtzinger et al., 2005

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Phenotype

Phenotype resulting from MO1-gata4

Phenotype	Fish	Figures
caudal fin blood circulation decreased process quality, abnormal	sd2Tg + MO1-gata4	Fig. 2 , Fig. 7 from Torregroza et al., 2012
caudal vein plexus malformed, abnormal	sd2Tg; y1Tg + MO1-gata4	Fig. 2 , Fig. 3 from Torregroza et al., 2012
embryonic heart tube left/right pattern formation disrupted, abnormal	TL + MO1-gata4	Fig. 5 from Lin et al., 2009
heart malformed, abnormal	twu34Tg + MO1-gata4	Fig. S4 from Gupta et al., 2013
heart looping decreased occurrence, abnormal	twu34Tg + MO1-gata4	Fig. S4 from Gupta et al., 2013

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Phenotype of all Fish created by or utilizing MO1-gata4

Phenotype	Fish	Conditions	Figures
heart looping disrupted, abnormal	TL + MO1-gata4	standard conditions	Fig. 5 from Lin et al., 2009
embryonic heart tube left/right pattern formation disrupted, abnormal	TL + MO1-gata4	standard conditions	Fig. 5 from Lin et al., 2009
posterior lateral line neuron projection mislocalised, abnormal	WT + MO1-gata4	standard conditions	Fig. 6 from Torregroza et al., 2012
posterior lateral line neuron decreased branchiness, abnormal	WT + MO1-gata4	standard conditions	Fig. 6 from Torregroza et al., 2012
trunk lacks parts or has fewer parts of type neuromast, abnormal	WT + MO1-gata4	standard conditions	Fig. 6 from Torregroza et al., 2012

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Citations

Include unpublished citations

Guo, S., Zhang, Y., Zhou, T., Wang, D., Weng, Y., Chen, Q., Ma, J., Li, Y.P., Wang, L. (2018) GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1. Cell death and differentiation. 25(11):1996-2009
Miyagi, H., Nag, K., Sultana, N., Munakata, K., Hirose, S., Nakamura, N. (2016) Characterization of the zebrafish cx36.7 gene promoter: Its regulation of cardiac-specific expression and skeletal muscle-specific repression. Gene. 577(2):265-74
Gupta, V., Gemberling, M., Karra, R., Rosenfeld, G.E., Evans, T., and Poss, K.D. (2013) An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle. Current biology : CB. 23(13):1221-7
Rawnsley, D.R., Xiao, J., Lee, J.S., Liu, X., Mericko-Ishizuka, P., Kumar, V., He, J., Basu, A., Lu, M., Lynn, F.C., Pack, M., Gasa, R., Kahn, M.L. (2013) The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. The Journal of biological chemistry. 288:24429-40
Rosenfeld, G.E., Mercer, E.J., Mason, C.E., and Evans, T. (2013) Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis. Developmental Biology. 381(2):389-400
Torregroza, I., Holtzinger, A., Mendelson, K., Liu, T.C., Hla, T., and Evans, T. (2012) Regulation of a Vascular Plexus by gata4 Is Mediated in Zebrafish through the Chemokine sdf1a. PLoS One. 7(10):e46844
Chen, Y.C., Wu, B.K., Chu, C.Y., Cheng, C.H., Han, H.W., Chen, G.D., Lee, M.T., Hwang, P.P., Kawakami, K., Chang, C.C., and Huang, C.J. (2010) Identification and characterization of alternative promoters of zebrafish Rtn-4/Nogo genes in cultured cells and zebrafish embryos. Nucleic acids research. 38(14):4635-4650
Rikin, A., and Evans, T. (2010) The tbx/bHLH transcription factor mga regulates gata4 and organogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(2):535-547
Lin, X., and Xu, X. (2009) Distinct functions of Wnt/{beta}-catenin signaling in KV development and cardiac asymmetry. Development (Cambridge, England). 136(2):207-217
Shin, D., Shin, C.H., Tucker, J., Ober, E.A., Rentzsch, F., Poss, K.D., Hammerschmidt, M., Mullins, M.C., and Stainier, D.Y. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development (Cambridge, England). 134(11):2041-2050

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