gata4

ID

ZDB-GENE-980526-476

Name

GATA binding protein 4

Symbol

gata4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; heart morphogenesis; and swim bladder formation. Predicted to be active in nucleus. Is expressed in several structures, including endocrine system; gut; liver and biliary system; mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

91 figures from 72 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gata4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
atrial heart septal defect 2	Alliance	Atrial septal defect 2	607941
atrioventricular septal defect	Alliance	Atrioventricular septal defect 4	614430
tetralogy of Fallot	Alliance	Tetralogy of Fallot	187500
ventricular septal defect	Alliance	Ventricular septal defect 1	614429
		?Testicular anomalies with or without congenital heart disease	615542

Associated With gata4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000679	Zinc finger, GATA-type
Domain	IPR008013	GATA-type transcription activator, N-terminal
Family	IPR016375	Transcription factor GATA-4/5/6
Family	IPR039355	Transcription factor GATA
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type