Gene

gata4

ID
ZDB-GENE-980526-476
Name
GATA binding protein 4
Symbol
gata4 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development; cardiac muscle tissue regeneration; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin. Is expressed in several structures, including cardiac muscle myoblast; digestive system; mesoderm; pericardial region; and reproductive system. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4).
Genome Resources
Note
None
Expression
All Expression Data
70 figures from 51 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gata4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 2 Alliance Atrial septal defect 2 607941
atrioventricular septal defect Alliance Atrioventricular septal defect 4 614430
tetralogy of Fallot Alliance Tetralogy of Fallot 187500
ventricular septal defect Alliance Ventricular septal defect 1 614429
?Testicular anomalies with or without congenital heart disease 615542
Associated With gata4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Domain IPR008013 GATA-type transcription activator, N-terminal
Family IPR016375 Transcription factor GATA-4/5/6
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Domain Details Per Protein
Protein Length GATA-type transcription activator, N-terminal Transcription factor GATA Transcription factor GATA-4/5/6 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:A0A0R4ILP3 352
UniProtKB:Q9PTJ2 338
UniProtKB:Q09JY7 352
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations