FIGURE

Fig. 4

ID

ZDB-FIG-260617-10

Publication

Martin et al., 2026 - Nr2f1a and Isl1 repress acquisition of epicardial identity in venous atrial cardiomyocytes

Other Figures

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Fig. 4

Cells in the venous atria of nr2f1a;isl1 mutants lack Myh6. (A-D″) Optical sections of the venous pole of wild-type, isl1^−/−, nr2f1a^−/− and nr2f1a^−/−;isl1^−/− hearts at 96 hpf stained for Myh6 (blue), Myh7 (red) and fgf13a:EGFP (green). In the schematics, Myh7 (red), Myh6 (blue), Myh6 + Myh7 (orange) and fgf13a:EGFP (green) are shown. Overlap of Myh6 and fgf13a:EGFP in myocardium in A-A″ and C-C″ (white arrows). (D-D″) A fgf13a:EGFP⁺ cell in a gap of Myh6 (yellow arrows), a fgf13a:EGFP⁺ cell on the outside of the atrial myocardial wall (red arrows) and a fgf13a:EGFP⁺/Myh6⁺ cell in the atrial myocardial wall (blue arrows). Scale bar: 10 μm. Wild type (n=9), nr2f1a^−/− (n=11), isl1^−/− (n=4) and nr2f1a^−/−;isl1^−/− (n=13).

Expression Data

Gene:	EGFP
Antibodies:	Ab-S46 Ab3-vmhc
Fish:	isl1a^{ci1032/ci1032}; sqet33mi59BEt/sqet33mi59BEt nr2f1a^{ci1009/ci1009}; sqet33mi59BEt/sqet33mi59BEt isl1a^{ci1032/ci1032}; nr2f1a^{ci1009/ci1009}; sqet33mi59BEt/sqet33mi59BEt
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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