FIGURE

Figure S5.

ID

ZDB-FIG-250705-29

Publication

Abgueguen et al., 2025 - Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models

Other Figures

All Figure Page

Back to All Figure Page

Figure S5.

Impact of TDP-43^G348C protein expression in motor neurons of zebrafish embryos.

(A) Number of cell body of motor neurons per segment of zebrafish embryos treated with vehicle or Sephin1 (n = 4 replicates per condition). (B) Axonal length of motor neurons in zebrafish embryos treated with vehicle or Sephin1 (n = 16 motor neurons per condition). mTDP43: zebrafish harboring the mTDP43 transgene without expressing the TDP43^G348C protein; mTDP43-HS: zebrafish expressing TDP43^G348C protein. *P < 0.05, ****P < 0.0001 Kruskal-Wallis test followed by Dunn’s multiple comparison test mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Life Sci Alliance