FIGURE

Figure 7.

ID

ZDB-FIG-250705-26

Publication

Abgueguen et al., 2025 - Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models

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Figure 7.

Sephin1 improves survival and locomotor function in zebrafish embryos expressing mutant TDP-43^G348C protein.

(A) Schematic of the experiment in mutated TDP-43 transgenic zebrafish embryos. (B) Survival percentage of zebrafish embryos expressing mutant TDP-43^G348C protein treated with vehicle or Sephin1 10 μM (**P < 0.01 unpaired t test, n = 12 replicates per condition). (C) Motor dysfunction percentage of zebrafish embryos expressing mutant TDP-43^G348C protein treated with vehicle or Sephin1 10 μM (**P < 0.01 unpaired t test, n = 12 replicates per condition). (D) Swim distance of zebrafish embryos expressing mutant TDP-43^G348C protein treated with vehicle or Sephin1 10 μM following the touch of the tail (****P < 0.0001 Mann-Whitney test n = 35–50 zebrafish per condition). (E) Swim duration of zebrafish embryos expressing mutant TDP-43^G348C protein treated with vehicle or Sephin1 10 μM following the touch of the tail (****P < 0.0001 Mann-Whitney test n = 35–53 zebrafish per condition). (F) Swim velocity of zebrafish embryos expressing mutant TDP-43^G348C protein treated with vehicle or Sephin1 10 μM following the touch of the tail (*P < 0.05 Mann-Whitney test, n = 35–50 zebrafish per condition). mTDP43-HS: zebrafish embryos expressing TDP43^G348C protein; mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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