FIGURE

Figure 8.

ID

ZDB-FIG-250705-30

Publication

Abgueguen et al., 2025 - Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models

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Figure 8.

Sephin1 improves motor neurons survival and axonal length in zebrafish embryos expressing mutant TDP-43^G348C protein.

(A) Representative pictures of spinal cord motor neurons of non-transgenic (Ntg) or mutant TDP-43^G348C protein expressing zebrafish embryos at 51 hpf and treated with vehicle or Sephin1 10 μM. (B) Cell body number of motor neurons measured per segment in zebrafish embryos expressing mutant TDP-43^G348C protein treated with vehicle or Sephin1 10 μM. (P = 0.0857 Mann-Whitney test, n = 4 replicates per condition). (C) Axonal length of motor neurons in zebrafish embryos expressing mutant TDP-43^G348C protein treated with vehicle or Sephin1 10 μM. (**P < 0.01 unpaired t test, n = 16 motor neurons per condition). Ntg-HS: WT zebrafish with 2 heat shock, mTDP43-HS: zebrafish embryos expressing TDP43^G348C protein mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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