FIGURE

Figure 5.

ID

ZDB-FIG-250705-23

Publication

Abgueguen et al., 2025 - Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models

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Figure 5.

Sephin1 improves survival of spinal cord motor neurons from SOD1^G93A female mice at 20 wk of age.

(A) Schematic of the experiment on female SOD1^G93A mice. (B) Representative pictures of motor neurons labeled with ChAT antibody in hemisection of spinal cord of WT (Ntg) and SOD1^G93A mice at 20 wk of age (magnification 4×). (C) Motor neuron number in spinal cord of 20 wk-old WT or SOD1^G93A mice. (D) Motor neuron number in spinal cord of 20-wk-old SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. (E) Plasmatic NFL level in 20-wk-old WT or SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. ^#P < 0.05 Mann-Whitney test; *P < 0.05 versus vehicle Kruskal-Wallis test followed by Dunn’s multiple comparison test; mean ± SEM n = 3–5 mice per condition.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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