Fig. 10

The stacked column chart illustrates the percentage of developing embryos with multiple deformities in neural tube (multiple neural tube defects) and isolated neural tube defect at 120 hpf in groups exposed to decitabine 1mM and myo-inositol 50µM (n=20). The multiple neural tube defects noted were neural tube curvature + scoliosis (10%), neural tube curvature + kyphosis + tail deformity (10%), fragmented neural tube + neural tube curvature (5%), fragmented neural tube + tail deformity (5%), tail deformity + neural tube curvature + split spine + craniofacial malformation (5%), craniofacial malformation + coiled neural tube (5%), craniofacial malformation + kyphosis + neural tube curvature (5%) and craniofacial malformation + lordosis + neural tube curvature (5%). The remaining 15% of developing embryos suffered from isolated neural tube defects (INTD) and 35% of developing embryos were observed normal