FIGURE

FIGURE 5

ID

ZDB-FIG-240118-21

Publication

Chen et al., 2024 - Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development

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FIGURE 5

Deficiencies of reticulospinal neurons in angpt1^–/– and itgb1b^–/– larval hindbrain. Expression of krox20 mRNA done by WISH shown in (A) lateral view and (C) dorsal view of 3-dpf angpt1^+/+ and (G) lateral view and (I) dorsal view of 4-dpf itgb1b^+/+ larvae. Fainter and misexpression patterns of krox20 were found in (B) lateral view and (D) dorsal view of 3-dpf angpt1^–/– brain and in (H) lateral view and (J) dorsal view of 4-dpf itgb1b^–/– brain. Retrograde labeling of 4-dpf genotyped larvae reveals the deficiencies of reticulospinal neurons in (F)angpt1^–/– and (L)itgb1b^–/– brains compared with their (E)angpt1^+/+ and (K)itgb1b^+/+ siblings. N = 5 per genotyped group in WISH and retrograde labeled analysis. Arrows indicate the abnormality of krox20 expression patterns in the angpt1^–/– and itgb1b^–/– hindbrain and lateral line nerves. Scale bars are 200 μm.

Expression Data

Gene:	egr2b
Fish:	WT angpt1^{sa14264/sa14264} itgb1b^mi371/mi371
Anatomical Terms:	hindbrain lateral line nerve
Stage Range:	Protruding-mouth to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	angpt1^{sa14264/sa14264} itgb1b^mi371/mi371
Observed In:	hindbrain hindbrain reticulospinal neuron lateral line nerve
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.