ZFIN ID: ZDB-GENE-980526-283
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: early growth response 2b
Gene Symbol: egr2b
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: egr2 (1), cb427 (1), id:ibd5073 (1), krox-20, krox20, krx20, wu:fb71h10, zgc:92210

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have DNA-binding activity transcription factor activity, RNA polymerase II-specific; involved in several processes, including animal organ development, animal organ development, and  ...
GENE EXPRESSION
All Expression Data: 528 figures from 367 publications
Directly Submitted Expression Data: 9 figures (19 images) from Rauch et al., 2003 [fb71h10]
  2 figures (2 images) from Kudoh et al., 2001 [ibd5073]
  6 figures (15 images) from Thisse et al., 2001 [cb427]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
egr2b_unrecovered Point Mutation Unknown Unknown ENU
fh227 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa10063 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa18210 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 5 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH egr2b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 1D Charcot-Marie-Tooth disease, type 1D 607678
    Charcot-Marie-Tooth disease type 3 Dejerine-Sottas disease 145900
    Charcot-Marie-Tooth disease type 4E Hypomyelinating neuropathy, congenital, 1 605253
    DISEASE ASSOCIATED WITH egr2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic organ development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013087 (1)
  • InterPro:IPR021849 (1)
  • InterPro:IPR036236 (1)
    		•
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
    		•
  • Pfam:PF00096 (1)
  • Pfam:PF11928 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA egr2b-201 (1) 2043
    Select Tool
    egr2b-202 (1) 853
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    egr2b interacts with
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM egr2b
    MARKER RELATIONSHIPS
    egr2bContained in: [BAC] DKEY-247F17 (1) (order this)
    egr2bEncodes: [EST] cb427 (1) (order this), fb71h10 (order this), ibd5073 (1) (order this)
    [cDNA] MGC:92210 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130997 (1) 2065bp
    Select Tool
    Genomic GenBank:CR354434 (1) 153813bp
    Select Tool
    Polypeptide UniProtKB:Q05159 (1) 412aa
    Select Tool
    Sequence Clusters UniGene:75080 (1)
    Sequence Information (all 21)
    OTHER egr2b GENE PAGES
  • Alliance (1)
  • Gene:30190 (1)
  • VEGA:OTTDARG00000027335 (1)
  • Ensembl(GRCz11):ENSDARG00000042826 (2)
    • ORTHOLOGY for egr2b (Chr: 12)
    CITATIONS (711)