ZFIN Gene: egr2b

ZFIN ID: ZDB-GENE-980526-283

ZFIN ID: ZDB-GENE-980526-283

Gene Name:

early growth response 2b

Gene Symbol:

egr2b

Sequence Ontology ID :

SO:0000704

Previous Names:

egr2 (1), cb427 (1), id:ibd5073 (1), krox-20, krox20, krx20, wu:fb71h10, zgc:92210

Location:

Chr: 12 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in embryonic organ development and nervous system development. Predicted to localize to the nucleus. ...

GENE EXPRESSION
All Expression Data:	530 figures from 369 publications
Directly Submitted Expression Data:	9 figures (19 images) from Rauch et al., 2003 [fb71h10]
	2 figures (2 images) from Kudoh et al., 2001 [ibd5073]
	6 figures (15 images) from Thisse et al., 2001 [cb427]
Wild-type Stages, Structures:	Cleavage:2-cell (0.75h-1.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
	anatomical structure brain glial cell (sensu Vertebrata) brain central nervous system cranial neural crest ectoderm glial cell head hindbrain dorsal region hindbrain hindbrain neural keel hindbrain neural plate hindbrain neural rod lateral line glial cell lateral line glial cell (sensu Vertebrata) lateral line lateral line system midbrain hindbrain boundary midbrain hindbrain boundary neural plate midbrain hindbrain boundary neural rod myelinating Schwann cell neural crest neural crest cell neural crest hindbrain neural keel neural plate neural rod neural tube otic vesicle posterior lateral line myelinating Schwann cell posterior lateral line nerve anatomical region posterior lateral line nerve myelinating Schwann cell posterior lateral line nerve presumptive rhombomere 3 presumptive rhombomere 4 presumptive rhombomere 5 presumptive rhombomere 6 rhombomere rhombomere 2 rhombomere 3 rhombomere 4 rhombomere 5 rhombomere 6 trigeminal placode trunk unspecified whole organism anterior region
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
egr2b_unrecovered	Point Mutation	Unknown	Unknown	ENU
fh227	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa10063	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa18210	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	5 figures from 4 publications
Observed in:	hindbrain hindbrain structural organization posterior lateral line nerve compact myelin posterior lateral line nerve myelin sheath posterior lateral line nerve presumptive rhombomere 3 presumptive rhombomere 5 rhombomere 3 rhombomere 5

DISEASE ASSOCIATED WITH egr2b HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 1D	Charcot-Marie-Tooth disease, type 1D	607678
Charcot-Marie-Tooth disease type 3	Dejerine-Sottas disease	145900
Charcot-Marie-Tooth disease type 4E	Hypomyelinating neuropathy, congenital, 1	605253

DISEASE ASSOCIATED WITH egr2b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	embryonic organ development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR013087 (1) InterPro:IPR021849 (1) InterPro:IPR036236 (1)	PROSITE:PS00028 (1) PROSITE:PS50157 (1)	Pfam:PF00096 (1) Pfam:PF11928 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	egr2b-201 (1)	2043	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	egr2b-202 (1)	853	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

egr2b interacts with

ANTIBODIESNo data available

PLASMIDS

Addgene

CONSTRUCTS WITH SEQUENCES FROM egr2b

MARKER RELATIONSHIPS

egr2bContained in:	[BAC] DKEY-247F17 (1) (order this)
egr2bEncodes:	[EST] cb427 (1) (order this), fb71h10 (order this), ibd5073 (1) (order this) [cDNA] MGC:92210 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_130997 (1)	2065bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR354434 (1)	153813bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q05159 (1)	412aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:75080 (1)

Sequence Information (all 21)

OTHER egr2b GENE PAGES

Alliance (1)

Gene:30190 (1)

VEGA:OTTDARG00000027335 (1)

Ensembl(GRCz11):ENSDARG00000042826 (2)

ORTHOLOGY for egr2b (Chr: 12)

CITATIONS (712)

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