ZFIN ID: ZDB-GENE-980526-283
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Gene Name: early growth response 2b
Gene Symbol: egr2b    Nomenclature History

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Previous Names: egr2 (1), cb427 (1), id:ibd5073 (1), krox-20, krox20, krx20, wu:fb71h10, zgc:92210

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in embryonic organ development and nervous system development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Is expressed in several structures, including nervous system; neural crest; neural keel; neural plate; and neural rod. Orthologous to human EGR2 (early growth response 2).
Genome Resources: Alliance (1),  Gene:30190 (1),  Ensembl(GRCz11):ENSDARG00000042826 (2)
GENE EXPRESSION
All Expression Data: 534 figures from 371 publications
Directly Submitted Expression Data: 9 figures (19 images) from Rauch et al., 2003 [fb71h10]
  2 figures (2 images) from Kudoh et al., 2001 [ibd5073]
  6 figures (15 images) from Thisse et al., 2001 [cb427]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
egr2b_unrecovered Point Mutation Unknown Unknown ENU
fh227 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa10063 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa18210 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-egr2b
    		2
    CRISPR2-egr2b
    		2
    CRISPR3-egr2b
    		2
    CRISPR4-egr2b
    		2
    CRISPR5-egr2b
    		2
    CRISPR6-egr2b
    		2
    CRISPR7-egr2b
    		2
    CRISPR8-egr2b
    		2
    CRISPR9-egr2b
    		2
    CRISPR10-egr2b 1
    MO1-egr2b N/A 1
    PHENOTYPE
    Data: 5 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH egr2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 1D Alliance Charcot-Marie-Tooth disease, type 1D 607678
    Charcot-Marie-Tooth disease type 3 Alliance Dejerine-Sottas disease 145900
    Charcot-Marie-Tooth disease type 4E Alliance Hypomyelinating neuropathy, congenital, 1 605253
    DISEASE ASSOCIATED WITH egr2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic organ development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR013087 Zinc finger C2H2-type
    Domain IPR021849 Early growth response, N-terminal
    Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA egr2b-201 (1)    Ensembl 2043
    Select Tool
    egr2b-202 (1)    Ensembl 853
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    egr2b interacts with
    ANTIBODIES No data available
    PLASMIDS
    Addgene:ZP17 Krox20
    CONSTRUCTS WITH SEQUENCES FROM egr2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(egr2b-gata2a:EGFP) egr2b,  gata2a EGFP Danio rerio 1 3
    Tg(hsp70l:egr2b-MYC,cryaa:EGFP) cryaa,  hsp70l EGFP,  egr2b,  MYC Danio rerio 1 1
    TgBAC(egr2b:Cre) egr2b Cre Danio rerio 1 1
    TgBAC(egr2b:GFP) egr2b GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    egr2b Contained in: [BAC] DKEY-247F17 (1) (order this)
    egr2b Encodes: [EST] cb427 (1) (order this), fb71h10 (order this), ibd5073 (1)
    [cDNA] MGC:92210 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130997 (1) 2065 nt
    Select Tool
    Genomic GenBank:CR354434 (1) 153813 nt
    Select Tool
    Polypeptide UniProtKB:Q05159 (1) 412 aa
    Select Tool
    Sequence Information (all 20)
    ORTHOLOGY for egr2b ( Chr: 12 )
    CITATIONS (719)