FIGURE

Figure 3

ID

ZDB-FIG-230228-312

Publication

Sugitani et al., 2023 - Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration

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Figure 3

Treatment of HSF1 MO (morpholino) significantly reduced the mRNA expression of Klf4, Oct4, and Sox2 6 h after ONI. (a) HSF1 MO or standard MO (Std. MO) was injected intraocularly 20 h before ONI. (b) HSF1 MO-treated group suppressed HSF1 mRNA expression compared to the Std. MO-treated group. Under these conditions, the mRNA expression of Klf4 (c), Oct4 (d), and Sox2 (e) was inhibited compared to the control (Std. MO) groups. Five experiments were repeated under each experimental condition. Data are expressed as the mean � SEM of independent experiments and analyzed by one-way ANOVA, followed by Scheffe?s multiple comparisons. Statistical significance was set at * p < 0.05.

Expression Data

Genes:	hsf1 klf4 pou5f3 sox2
Fish:	WT WT + MO2-hsf1
Condition:	compression injury: cranial nerve II
Knockdown Reagent:	MO2-hsf1
Anatomical Term:	retina
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT WT + MO2-hsf1
Condition:	compression injury: cranial nerve II
Knockdown Reagent:	MO2-hsf1
Observed In:	retina
Stage:	Adult

Phenotype Detail

Acknowledgments

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