Gene

pou5f3

ID
ZDB-GENE-980526-485
Name
POU domain, class 5, transcription factor 3
Symbol
pou5f3 Nomenclature History
Previous Names
  • oct4
  • pou2 (1)
  • pou5f1 (1)
  • cb197 (1)
  • chunp6868
  • etID49452.21 (1)
  • gp-9
  • gp9
  • spg
  • spiel ohne grenzen
  • spiel-ohne-grenzen (1)
  • wu:fd18d06
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Enables several functions, including DNA-binding transcription factor activity; chromatin binding activity; and protein heterodimerization activity. Involved in nucleosome organization. Acts upstream of with a positive effect on cell dedifferentiation. Acts upstream of or within several processes, including brain development; embryonic morphogenesis; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleus. Is expressed in several structures, including blastoderm; blastodisc; ectoderm; gonad; and hindbrain neural keel. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Orthologous to human POU5F1 (POU class 5 homeobox 1); POU5F1B (POU class 5 homeobox 1B); and POU5F2 (POU domain class 5, transcription factor 2).
Genome Resources
Note
The gene name was updated on May 20, 2013 to reflect the evolutionary relationship of this gene with the mammalian POU domain, class 5 genes. The data suggests that there is not a true ortholog in human and mouse for this zebrafish gene. The synteny, amino acid alignment and phylogenetic trees suggest that a duplication event occurred in the last common ancestor of extant cartilaginous fishes and bony fishes resulting in 2 POU5 genes. Subsequently, the bony fishes, marsupials and birds maintained pou5f3, but lost pou5f1 which was maintained in eutherians and marsupials. This gene is an apparent ortholog (AA, CL) with the opposum, xenopus and chicken Pou5f3 genes.
Comparative Information
Expression
All Expression Data
53 figures from 28 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
55 figures from 19 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pou5f3 Human Ortholog
No data available
Associated With pou5f3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR000327 POU-specific domain
Domain IPR001356 Homeobox domain
Domain IPR013847 POU domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR010982 Lambda repressor-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Lambda repressor-like, DNA-binding domain superfamily POU domain POU-specific domain
UniProtKB:Q7ZU11 472
UniProtKB:A0A0R4I9C7 472
UniProtKB:Q90270 472
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-pou5f3 polyclonal Rabbit
  • WB
1
Ab2-pou5f3 polyclonal Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations