ZFIN ID: ZDB-GENE-980526-485
Gene Name: POU domain, class 5, transcription factor 3
Gene Symbol: pou5f3
Sequence Ontology ID : SO:0000704

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Previous Names: oct4, pou2 (1), pou5f1 (1), cb197 (1), chunp6868, etID49452.21 (1), gp-9, gp9, spg, spiel ohne grenzen, spiel-ohne-grenzen (1), wu:fd18d06

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
Note: The gene name was updated on May 20, 2013 to reflect the evolutionary relationship of this gene with the mammalian POU domain, class 5 genes. The data suggests that there is not a true ortholog in human and mouse for this zebrafish gene. The synteny, amino acid alignment and phylogenetic trees suggest that a duplication event occurred in the last common ancestor of extant cartilaginous fishes and bony fishes resulting in 2 POU5 genes. Subsequently, the bony fishes, marsupials and birds maintained pou5f3, but lost pou5f1 which was maintained in eutherians and marsupials. This gene is an apparent ortholog (AA, CL) with the opposum, xenopus and chicken Pou5f3 genes.
AUTOMATED DESCRIPTION
Exhibits several functions, including DNA-binding activity transcription factor activity, chromatin binding activity, and protein heterodimerization activity; involved in several processes, including  ...
GENE EXPRESSION
All Expression Data: 42 figures from 25 publications
Directly Submitted Expression Data: 2 figures (4 images) from Rauch et al., 2003 [MGC:55202]
  6 figures (17 images) from Thisse et al., 2001 [cb197]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
e68 Unknown Unknown Unknown ENU
e713 Point Mutation Unknown Missense ENU
hi349Tg Transgenic Insertion Exon 3 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1757Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1940Tg Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ihb137 Small Deletion Unknown Unknown CRISPR
    ihb138 Small Deletion Unknown Unknown CRISPR
    la013973Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m216 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m308 Point Mutation Acceptor Splice Site of Exon 5 Frameshift ENU
    m793 Point Mutation Acceptor Splice Site of Exon 2 Frameshift, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pou5f3_unspecified Unspecified Unknown Unknown
    sa1294 Point Mutation Unknown Premature Stop ENU
    sa1329 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wi270Tg Transgenic Insertion Unknown Unknown DNA
    Targeting reagents:
    PHENOTYPE
    Data: 53 figures from 17 publications
    Observed in:
    DISEASE ASSOCIATED WITH pou5f3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pou5f3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000327 (1)
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR010982 (1)
  • InterPro:IPR013847 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS00035 (1)
  • PROSITE:PS00465 (1)
  • PROSITE:PS50071 (1)
  • PROSITE:PS51179 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF00157 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pou5f3-201 (1) 2476
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pou5f3
    MARKER RELATIONSHIPS
    pou5f3Contained in: [BAC] CH73-205E12 (1) (order this)
    pou5f3Contains: [SNP] rs3729086 (1)
    pou5f3Encodes: [EST] cb197 (1) (order this), fd18d06
    [STS] chunp6868
    [cDNA] MGC:55202 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131112 (1) 2425bp
    Genomic GenBank:FP089537 (1) 98611bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4I9C7 (1) 472aa
    Sequence Clusters UniGene:258 (1)
    Sequence Information (all 27)
    OTHER pou5f3 GENE PAGES
  • Alliance (1)
  • Gene:30333 (1)
  • VEGA:OTTDARG00000032106 (1)
  • Ensembl(GRCz11):ENSDARG00000044774 (1)
  • ORTHOLOGY for pou5f3 (Chr: 21)
    CITATIONS (153)