Gene
sox2
- ID
- ZDB-GENE-030909-1
- Name
- SRY-box transcription factor 2
- Symbol
- sox2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables chromatin binding activity and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Acts upstream of or within several processes, including fin regeneration; nervous system development; and otic placode development. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural keel; and presumptive structure. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; oral cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX2 (SRY-box transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 181 figures from 108 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb236 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hg138 | Allele with one delins | 5' UTR | Unknown | CRISPR | |
hg139 | Allele with one delins | 5' UTR | Unknown | CRISPR | |
hg140 | Allele with one delins | 5' UTR | Unknown | CRISPR | |
ihb451 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
x50 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
zf3399 | Allele with one deletion | Exon 1 | Unknown | TALEN |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
syndromic microphthalmia 3 | Alliance | Microphthalmia, syndromic 3 | 206900 |
syndromic microphthalmia 3 | Alliance | Optic nerve hypoplasia and abnormalities of the central nervous system | 206900 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | SRY-related HMG-box transcription factor-like | Transcription factor SOX |
---|---|---|---|---|---|---|
UniProtKB:Q6P0E1 | InterPro | 315 |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab3-sox2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
42 | |
Ab5-sox2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
5 | |
Ab1-sox2 | polyclonal | Rabbit |
|
Millipore
|
26 | ||
Ab13-sox2 | monoclonal | IgG1 | Mouse |
|
GeneTex
|
4 | |
Ab2-sox2 | polyclonal | IgG | Rabbit |
|
LifeSpan BioSciences, Inc.
|
4 | |
Ab4-sox2 | polyclonal | IgG | Goat |
|
R&D Systems
|
8 |
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:sox2) |
|
| 1 | (8) | |
Tg(-2.9sox2:EGFP) |
|
| 1 | Fontenas et al., 2021 | |
Tg(hsp70l:sox2-2A-NLS-KikGR) |
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-242D14 | ZFIN Curated Data | |
Encodes | EST | cb236 | Thisse et al., 2001 | |
Encodes | EST | fb83g04 | ZFIN Curated Data | |
Encodes | EST | fc14d07 | ZFIN Curated Data | |
Encodes | cDNA | MGC:65860 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77389 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213118 (1) | 2120 nt | ||
Genomic | GenBank:FP102167 (2) | 98106 nt | ||
Polypeptide | UniProtKB:Q6P0E1 (1) | 315 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Srivastava, P.P., Bhasin, S., Shankaran, S.S., Roger, C., Ramachandran, R., Minocha, S. (2024) A reproducible method to study traumatic injury-induced zebrafish brain regeneration. Biology methods & protocols. 9:bpae073bpae073
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Wang, Y., Yuan, B., Liu, W., Cui, J., Zhou, X., Yuan, L., Deng, Z., Li, Y., Yuan, X. (2024) The Xaliproden Nanoscale Zirconium-Porphyrin Metal-Organic Framework (XAL-NPMOF) Promotes Photoreceptor Regeneration Following Oxidative and Inflammatory Insults. International Journal of Nanomedicine. 19:103871040010387-10400
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
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