ZFIN is now using GRCz12tu for Genomic Data
Gene
sox2
- ID
- ZDB-GENE-030909-1
- Name
- SRY-box transcription factor 2
- Symbol
- sox2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables chromatin binding activity and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Acts upstream of or within several processes, including fin regeneration; nervous system development; and otic placode development. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural keel; and presumptive structure. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; oral cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX2 (SRY-box transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 194 figures from 118 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb236 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic microphthalmia 3 | Alliance | Microphthalmia, syndromic 3 | 206900 |
| syndromic microphthalmia 3 | Alliance | Optic nerve hypoplasia and abnormalities of the central nervous system | 206900 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | SRY-related HMG-box transcription factor-like | Transcription factor SOX |
|---|---|---|---|---|---|---|
| UniProtKB:Q6P0E1 | InterPro | 315 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-sox2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
43 | |
| Ab5-sox2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
5 | |
| Ab1-sox2 | polyclonal | Rabbit |
|
Millipore
|
26 | ||
| Ab13-sox2 | monoclonal | IgG1 | Mouse |
|
GeneTex
|
4 | |
| Ab2-sox2 | polyclonal | IgG | Rabbit |
|
LifeSpan BioSciences, Inc.
|
4 | |
| Ab4-sox2 | polyclonal | IgG | Goat |
|
R&D Systems
|
10 |
Plasmids
- Genome Browsers