Gene

sox2

ID
ZDB-GENE-030909-1
Name
SRY-box transcription factor 2
Symbol
sox2 Nomenclature History
Previous Names
  • soxp (1)
  • cb236 (1)
  • wu:fb83g04
  • wu:fc14d07
  • zgc:65860
  • zgc:77389
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Exhibits chromatin binding activity and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including animal organ development; fin regeneration; and otic placode development. Predicted to localize to nuclear chromatin. Is expressed in several structures, including immature eye; nervous system; neural keel; neural rod; and presumptive structure. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX2 (SRY-box transcription factor 2).
Genome Resources
Note
None
Expression
All Expression Data
138 figures from 80 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sox2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
syndromic microphthalmia 3 Alliance Microphthalmia, syndromic 3 206900
syndromic microphthalmia 3 Alliance Optic nerve hypoplasia and abnormalities of the central nervous system 206900
Associated With sox2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Family IPR022097 Transcription factor SOX
Family IPR032643 Transcription factor SOX-2
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily Transcription factor SOX Transcription factor SOX-2
UniProtKB:Q6P0E1 315
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-sox2 polyclonal IgG Rabbit
  • IHC
Abcam plc
21
Ab5-sox2 polyclonal IgG Rabbit
Abcam plc
3
Ab1-sox2 polyclonal Rabbit
  • IHC
Millipore
23
Ab2-sox2 polyclonal IgG Rabbit
  • IHC
  • WB
LifeSpan BioSciences, Inc.
4
Ab4-sox2 polyclonal IgG Goat
  • WB
R&D Systems
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations