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ZIRC
ZFIN ID: ZDB-GENE-030909-1
Gene Name: SRY-box transcription factor 2
Gene Symbol: sox2    Nomenclature History

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Previous Names: soxp (1), cb236 (1), wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits chromatin binding activity and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including animal organ development; fin regeneration; and otic placode development. Predicted to localize to the nuclear transcription factor complex. Human ortholog(s) of this gene implicated in breast cancer; microphthalmia; and nasal cavity cancer. Is expressed in several structures, including immature eye; nervous system; neural keel; neural rod; and presumptive structure. Orthologous to human SOX2 (SRY-box transcription factor 2).
Genome Resources: Alliance (1), Gene:378723 (1), Ensembl(GRCz11):ENSDARG00000070913 (2)
GENE EXPRESSION
All Expression Data: 132 figures from 77 publications
Directly Submitted Expression Data: 12 figures (28 images) from Rauch et al., 2003 [fb83g04]
  6 figures (19 images) from Thisse et al., 2001 [cb236]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
x50 Small Deletion Unknown Frameshift, Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-sox2
1
MO1-sox2 N/A 2
MO2-sox2 N/A 3
MO3-sox2 N/A 7
MO4-sox2 N/A 6
MO5-sox2,sox3 N/A 3
MO6-sox2 N/A 1
MO7-sox2 N/A 1
TALEN1-sox2 1
TALEN2-sox2 1
DISEASE ASSOCIATED WITH sox2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
microphthalmia Alliance Microphthalmia, syndromic 3 206900
Optic nerve hypoplasia and abnormalities of the central nervous system 206900
DISEASE ASSOCIATED WITH sox2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of DNA-binding transcription factor activity (more)
Cellular Component transcription factor complex (more)
Molecular Function chromatin binding (more)
GO Terms (all 24)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sox2-201 (1)    Ensembl 2072
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab3-sox2 polyclonal IgG Rabbit IHC