Gene
hsf1
- ID
- ZDB-GENE-000616-16
- Name
- heat shock transcription factor 1
- Symbol
- hsf1 Nomenclature History
- Previous Names
-
- hsf1a
- hsf1b
- HSF1c (1)
- zHSF1a
- zHSF1b
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Exhibits sequence-specific DNA binding activity. Involved in lens development in camera-type eye and response to heat. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Huntington's disease. Is expressed in brain; head; and otic vesicle. Orthologous to human HSF1 (heat shock transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000232 | Heat shock factor (HSF)-type, DNA-binding |
| Domain | IPR010542 | Vertebrate heat shock transcription factor, C-terminal domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Heat shock factor (HSF)-type, DNA-binding | Vertebrate heat shock transcription factor, C-terminal domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q1LXV0
|
497 | ||||
|
UniProtKB:F6P697
|
523 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-hsf1 | monoclonal | IgG1 | Rat |
|
Thermo Fisher Scientific (Lab Vision)
|
2 |
Plasmids
No data available