FIGURE

Figure 2

ID

ZDB-FIG-230228-175

Publication

Le Mentec et al., 2023 - A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation

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Figure 2

Screening of the steatogenic molecules with the StAZ bioassay. Zebrafish larvae at 3 dpf were exposed to selected steatogenic controls: high-fat diet (HFD), ethanol 1% v/v (EtOH 1%), amiodarone (1 µM), valproate (10/60 µM) or TCDD (1/3 nM). Following exposure, larvae were euthanized and fixed, and steatosis score (cf. Figure 1b) was calculated based on Nile red staining and image-based automated analysis after confocal microscopy acquisition. Values are mean +/− SEM, with the number of batches and larvae indicated in the table underneath the graph. *** p < 0.001, by comparison with control group using Kruskal–Wallis test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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