FIGURE

Figure 5

ID

ZDB-FIG-230228-178

Publication

Le Mentec et al., 2023 - A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation

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Figure 5

Heatmap showing the impact of DDE on mRNA expression of different genes related to metabolic pathways. mRNA expression was evaluated by RT-qPCR gene expression analysis by using the microfluidic Fluidigm-Biomark technology. Zebrafish larvae were exposed to DDE (from 1 nM to 10 µM) during 48 h, from 3 to 5 dpf. mRNA expressions of 90 genes related to nuclear receptors, lipid homeostasis, liver metabolism, inflammation and oxidative stress were analysed; results are shown as a heatmap (each raw represents an independent mRNA sample extracted from a pool of zebrafish larvae). Data are expressed as mean expressions relative to mRNA levels measured in DMSO control larvae, set at 0 (log 2 fold change) (n ≥ 8).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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