FIGURE

Figure 6

ID

ZDB-FIG-230228-179

Publication

Le Mentec et al., 2023 - A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation

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Figure 6

Impact of HFD and DDE on mRNA expression of several genes involved in lipid metabolism characteristic of steatosis and in toxicity. mRNA expression was evaluated by RT-qPCR gene expression analysis by using the microfluidic Fluidigm-Biomark technology. Zebrafish larvae were exposed to HFD or DDE (from 1 nM to 10 µM) during 48 h, from 3 to 5 dpf. mRNA expressions of genes related to fatty acid metabolism (a), sphingolipid and cholesterol metabolism (b), nuclear receptors, (c) and inflammation and oxidative stress (d), are shown. Data are expressed relative to mRNA levels measured in DMSO control larvae, set at 0 (log 2 fold change). Values are the mean ± SEM (n ≥ 8). * p < 0.05, ** p < 0.01, *** p < 0.001, by comparison with control group using ANOVA and Dunnett’s test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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