Gene

apoeb

ID
ZDB-GENE-980526-368
Name
apolipoprotein Eb
Symbol
apoeb Nomenclature History
Previous Names
  • ApoE-2 (1)
  • apoe
  • cb82 (1)
  • hm:zeh1311
  • wu:fa03d06 (1)
  • wu:fa97a11 (1)
  • wu:fc95h12 (1)
  • wu:fj54e06 (1)
  • zeh1311
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have anion binding activity; identical protein binding activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including cholesterol catabolic process; lipoprotein metabolic process; and triglyceride-rich lipoprotein particle clearance. Predicted to localize to several cellular components, including high-density lipoprotein particle; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is expressed in several structures, including digestive system; epidermis; fin bud; median fin; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
Genome Resources
Note
None
Expression
All Expression Data
68 figures from 37 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apoeb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 1 Alliance {?Macular degeneration, age-related} 603075
Alzheimer's disease 2 Alliance Alzheimer disease 2 104310
Alzheimer's disease 3 Alliance {?Alzheimer disease, protection against, due to APOE3-Christchurch} 607822
hyperlipoproteinemia type III Alliance Hyperlipoproteinemia, type III 617347
hyperlipoproteinemia type III Alliance {Coronary artery disease, severe, susceptibility to} 617347
sea-blue histiocytosis Alliance Sea-blue histiocyte disease 269600
Lipoprotein glomerulopathy 611771
Associated With apoeb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000074 Apolipoprotein A/E
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations