Gene
apoeb
- ID
- ZDB-GENE-980526-368
- Name
- apolipoprotein Eb
- Symbol
- apoeb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including cholesterol efflux; phospholipid efflux; and triglyceride-rich lipoprotein particle clearance. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in several structures, including epidermis; fin bud; hematopoietic cell; median fin; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 90 figures from 55 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb82 (8 images)
- eu173 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hu et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 1 | Alliance | {?Macular degeneration, age-related} | 603075 |
| Alzheimer's disease 2 | Alliance | Alzheimer disease 2 | 104310 |
| Alzheimer's disease 3 | Alliance | {?Alzheimer disease, protection against, due to APOE3-Christchurch} | 607822 |
| hyperlipoproteinemia type III | Alliance | Hyperlipoproteinemia, type III | 617347 |
| hyperlipoproteinemia type III | Alliance | {Coronary artery disease, severe, susceptibility to} | 617347 |
| sea-blue histiocytosis | Alliance | Sea-blue histiocyte disease | 269600 |
| Lipoprotein glomerulopathy | 611771 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|
|
UniProtKB:O42364
|
281 |
Interactions and Pathways
No data available
Plasmids