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ZDB-FIG-180710-42

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Follain et al., 2018 - Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

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Fig. S5

Tuning PMA with two other drugs also perturb the behavior of CTCs in vivo. (A) Quantification of the PMA with nifedipin (5μM) treatment compared to vehicle. (B) Number and location of arrested CTCs 3hpi using heatmapping, and quantification (C). (D) Adhesion and migration assay results of TCs assessed in presence of nifedipin. (E) Quantification of the PMA with norepinephrine (500μM) treatment compared to control. (F) Number and location of arrested CTCs 3hpi using heatmapping, and quantification (G). Data normalized to vehicle AVJ mean. (H) Adhesion and migration of TCs is assessed in presence of norepinephrine. (I) Heatmaps and quantification of the extravasation efficacy of 1675, JIMT-1 and ZMEL cells 24 hpi. Values in (A), (C-F), (H-J) and (I) are mean + SD.

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Reprinted from Developmental Cell, 45, Follain, G., Osmani, N., Azevedo, A.S., Allio, G., Mercier, L., Karreman, M.A., Solecki, G., Garcia Leòn, M.J., Lefebvre, O., Fekonja, N., Hille, C., Chabannes, V., Dollé, G., Metivet, T., Hovsepian, F., Prudhomme, C., Pichot, A., Paul, N., Carapito, R., Bahram, S., Ruthensteiner, B., Kemmling, A., Siemonsen, S., Schneider, T., Fiehler, J., Glatzel, M., Winkler, F., Schwab, Y., Pantel, K., Harlepp, S., Goetz, J.G., Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells, 33-52.e12, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell