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Fig. S2

ID

ZDB-FIG-180710-39

Publication

Follain et al., 2018 - Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

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Fig. S2

Permissive flow profiles allow adhesion of CTCs to ECs. (A) Experimental set up, representative image and quantifications of the 10-?m beads injection. (B) Experimental set up and results of the adhesion efficacy regarding the temperature. (C) Experimental set up and quantification of the measured adhesion rupture force (n=8 and 6) of attached TC (top). Annotated image sequence from Movie 6 showing the detachment of a TC from the endothelial monolayer (bottom). (D) Experimental set up and quantification of the ratio of effective adhesion events upon OT (left) and OT-mediated detachment events (right) using siRNA-treated TCs. (E) Quantification of the Western blot analysis in Fig.2E and representative immunostaining images from siITGB1 cells.

Expression Data

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Antibody Labeling

Phenotype Data

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Reprinted from Developmental Cell, 45, Follain, G., Osmani, N., Azevedo, A.S., Allio, G., Mercier, L., Karreman, M.A., Solecki, G., Garcia Le�n, M.J., Lefebvre, O., Fekonja, N., Hille, C., Chabannes, V., Doll�, G., Metivet, T., Hovsepian, F., Prudhomme, C., Pichot, A., Paul, N., Carapito, R., Bahram, S., Ruthensteiner, B., Kemmling, A., Siemonsen, S., Schneider, T., Fiehler, J., Glatzel, M., Winkler, F., Schwab, Y., Pantel, K., Harlepp, S., Goetz, J.G., Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells, 33-52.e12, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell