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Follain et al., 2018 - Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

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Fig. S1

CTCs arrest and extravasate in vascular regions with permissive flow profiles. (A) Experimental workflow. (B) Maximum projection of confocal stack of the zebrafish brain vasculature (green) containing extravasated TCs (red). (C) Heatmaps showing the adhesion pattern of 6 cell lines in the caudal plexus of the zebrafish embryos. (D) Confocal Z-projection of zebrafish posterior caudal plexus (CP) at 2 dpf. (E) Partial 3D segmentation (Amira) based on confocal acquisition (D). (F) Simplified AOC model of the zebrafish CP. (G) Image extracted from Movie S3, showing flow simulation results in the AOC model. (H) Velocity profiles obtained from flow simulation at several positions indicated in F. (I) Graphical representation of minimum, maximum and mean values of the blood flow velocity over the 5 positions from F.

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Reprinted from Developmental Cell, 45, Follain, G., Osmani, N., Azevedo, A.S., Allio, G., Mercier, L., Karreman, M.A., Solecki, G., Garcia Le�n, M.J., Lefebvre, O., Fekonja, N., Hille, C., Chabannes, V., Doll�, G., Metivet, T., Hovsepian, F., Prudhomme, C., Pichot, A., Paul, N., Carapito, R., Bahram, S., Ruthensteiner, B., Kemmling, A., Siemonsen, S., Schneider, T., Fiehler, J., Glatzel, M., Winkler, F., Schwab, Y., Pantel, K., Harlepp, S., Goetz, J.G., Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells, 33-52.e12, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell