FIGURE

Fig. 6

ID
ZDB-FIG-150319-23
Publication
Cheng et al., 2015 - The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis
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Fig. 6

Knockdown of Her2 induces premature differentiation of neuronal precursors. (A) Injection of her2 morpholino downregulated the expression of neurog1, deltaA, ascl1a, and ascl1b and upregulated the expression of elavl3 at the bud stage. The phenotypes caused by morpholino injection could be rescued by concomitant injection with her2 cRNA. (B) qPCR analysis confirmed the results obtained by in situ hybridization. (C) Compared with the controls, injection of her2 cRNA did not cause a significant alteration in proneural markers (neurog1, deltaA, ascl1a, and ascl1b). (D) qPCR quantification of the results in C. **, p<0.01; n.s., not significant.

Expression Data
Genes:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage: Bud

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage: Bud

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 397(1), Cheng, Y.C., Chiang, M.C., Shih, H.Y., Ma, T.L., Yeh, T.H., Huang, Y.C., Lin, C.Y., Lin, S.J., The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis, 116-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.