FIGURE

Fig. 6

ID

ZDB-FIG-150319-23

Publication

Cheng et al., 2015 - The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis

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Fig. 6

Knockdown of Her2 induces premature differentiation of neuronal precursors. (A) Injection of her2 morpholino downregulated the expression of neurog1, deltaA, ascl1a, and ascl1b and upregulated the expression of elavl3 at the bud stage. The phenotypes caused by morpholino injection could be rescued by concomitant injection with her2 cRNA. (B) qPCR analysis confirmed the results obtained by in situ hybridization. (C) Compared with the controls, injection of her2 cRNA did not cause a significant alteration in proneural markers (neurog1, deltaA, ascl1a, and ascl1b). (D) qPCR quantification of the results in C. ^**, p<0.01; n.s., not significant.

Expression Data

Genes:	ascl1a ascl1b dla elavl3 neurog1
Fish:	TU TU + MO2-her2
Knockdown Reagent:	MO2-her2
Anatomical Term:	neuroblast
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO2-her2
Knockdown Reagent:	MO2-her2
Observed In:	neuron differentiation
Stage:	Bud

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 397(1), Cheng, Y.C., Chiang, M.C., Shih, H.Y., Ma, T.L., Yeh, T.H., Huang, Y.C., Lin, C.Y., Lin, S.J., The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis, 116-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.