ZFIN ID: ZDB-GENE-980526-174
Gene Name: achaete-scute family bHLH transcription factor 1b
Gene Symbol: ascl1b    Nomenclature History

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Previous Names: ashb, Zash-1b (1), zashb

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to contribute to DNA-binding transcription factor activity. Involved in chordate embryonic development; endocrine pancreas development; and hindbrain morphogenesis. Predicted to localize to RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; neural plate; neural tube; neurons; and posterior neural keel. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to several human genes including ASCL2 (achaete-scute family bHLH transcription factor 2).
Genome Resources: Alliance (1),  Gene:30478 (1),  Ensembl(GRCz11):ENSDARG00000101628 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38638 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41003 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ulg002 Small Deletion Unknown Frameshift CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ascl1b 1
    MO1-ascl1b N/A 6
    DISEASE ASSOCIATED WITH ascl1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome, congenital 209880
    Haddad syndrome 209880
    DISEASE ASSOCIATED WITH ascl1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hindbrain morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ascl1b-203 (1)    Ensembl 1273
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ascl1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(ascl1b:EGFP-2A-Cre-ERT2) ascl1b 2ACreEGFPERT2 Danio rerio 1 1
    MARKER RELATIONSHIPS
    ascl1b Contained in: [BAC] CH211-210P4 (1)
    ascl1b Encodes: [EST] eu104 (1)
    [cDNA] MGC:85958 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131231 (1) 1248 nt
    Genomic GenBank:BX088691 (1) 150021 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8S0I4 (1) 863 aa
    Sequence Information (all 13)
    ORTHOLOGY for ascl1b ( Chr: 7 )
    CITATIONS (92)