Gene
ascl1a
- ID
- ZDB-GENE-980526-90
- Name
- achaete-scute family bHLH transcription factor 1a
- Symbol
- ascl1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in adenohypophysis development; hindbrain morphogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including digestive tract development; nervous system development; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including digestive system; nervous system; neural tube; neuronal stem cell; and optic cup. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 156 figures from 97 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu887 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:Q90259
|
196 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ascl1a-201
(1)
|
Ensembl | 1,977 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ascl1 | polyclonal | Rabbit |
|
Sigma-Aldrich
|
3 |
Plasmids
No data available