ZFIN Image: Cheng et al., 2015, Fig. 6

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Figure Caption

Fig. 6

Knockdown of Her2 induces premature differentiation of neuronal precursors. (A) Injection of her2 morpholino downregulated the expression of neurog1, deltaA, ascl1a, and ascl1b and upregulated the expression of elavl3 at the bud stage. The phenotypes caused by morpholino injection could be rescued by concomitant injection with her2 cRNA. (B) qPCR analysis confirmed the results obtained by in situ hybridization. (C) Compared with the controls, injection of her2 cRNA did not cause a significant alteration in proneural markers (neurog1, deltaA, ascl1a, and ascl1b). (D) qPCR quantification of the results in C. ^**, p<0.01; n.s., not significant.

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Acknowledgments

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Reprinted from Developmental Biology, 397(1), Cheng, Y.C., Chiang, M.C., Shih, H.Y., Ma, T.L., Yeh, T.H., Huang, Y.C., Lin, C.Y., Lin, S.J., The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis, 116-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.