FIGURE

Fig. 4

ID

ZDB-FIG-140709-37

Publication

Feng et al., 2010 - Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism

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Fig. 4

In situ validation of microarray hits whose expression is decreased in RA-treated embryos and increased in antagonist-treated embryos. (A–E) Dorsal views of five selected microarray hits (blue) and egr2b (red) at 11 hpf. Anterior is to the left in all panels. Column i: control (DMSO) treated; ii: 10 µM DEAB (RA synthesis antagonist) treated; iii: 0.33 µm RA-treated. The numbers in the upper right corners refer to the fold-change in expression level identified on the microarray. (F) Although not represented on the microarray, zebrafish rdh10a is increased in RA-depleted embryos and suppressed in RA-treated embryos.

Expression Data

Genes:	cdc42ep4a dusp2 egr2b her3 hey2 rdh10a tbx1
Fish:	AB
Conditions:	chemical treatment: 4-(diethylamino)benzaldehyde chemical treatment: all-trans-retinoic acid
Anatomical Terms:	endoderm hindbrain neural plate neural plate paraxial mesoderm posterior neural plate presumptive cephalic mesoderm presumptive rhombomere 3 presumptive rhombomere 5
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 338(1), Feng, L., Hernandez, R.E., Waxman, J.S., Yelon, D., and Moens, C.B., Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism, 1-14, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.