|ZFIN ID: ZDB-FIG-140626-11|
Fig. 4 Notch1a, Notch1b, and Notch3 together contribute to p2 progenitor maintenance. p2 Progenitors in the ventricular zone detected by irx3a (A) or nkx6.1 (B) were reduced in notch1a/notch1b/notch3 knockdown embryos (90%, irx3a, n=10; 80%, nkx6.1, n=10). Other single or double knockdown embryos did not show a striking reduction in irx3a (A) or nkx6.1 (B) expression compared with the notch1a/notch1b/notch3 knockdown embryos. All panels: side views of embryos at 24 hpf with anterior to the left, dorsal up. Dorsal and ventral borders of the neural tubes are shown by the dotted lines. Bar scale: 100 µm.
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Reprinted from Developmental Biology, 391(2), Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M., Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination, 196-206, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.