Gene

nkx6.1

ID
ZDB-GENE-040718-178
Name
NK6 homeobox 1
Symbol
nkx6.1 Nomenclature History
Previous Names
  • zgc:92879
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate commitment; enteroendocrine cell differentiation; and spinal cord motor neuron differentiation. Predicted to localize to nucleus. Is expressed in several structures, including DEL; endoderm; nervous system; neural tube; and pancreatic system. Orthologous to human NKX6-1 (NK6 homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
44 figures from 31 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nkx6.1 Human Ortholog
No data available
Associated With nkx6.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site
UniProtKB:Q6DGK5 312
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA nkx6.1-201 (1) Havana 2023 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-nkx6 monoclonal IgG1 , k Mouse
  • IHC
  • WB
Developmental Studies Hybridoma Bank
19
Ab1-nkx6 polyclonal Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations