ZFIN Morpholino: MO4-notch1a

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-notch1a

No data available

Phenotype

Phenotype resulting from MO4-notch1a

No data available

Phenotype of all Fish created by or utilizing MO4-notch1a

Phenotype	Fish	Conditions	Figures
hindbrain has extra parts of type Mauthner neuron, abnormal	WT + MO3-notch1a + MO4-notch1a	control	Fig. 7 from Banote et al., 2016
VeLD decreased amount, abnormal	nns5Tg + MO3-notch1a + MO4-notch1a	standard conditions	Fig. 5 from Okigawa et al., 2014
CiD increased amount, abnormal	nns5Tg + MO3-notch1a + MO4-notch1a	standard conditions	Fig. 5 from Okigawa et al., 2014
posterior lateral line ganglion neuron increased amount, abnormal	WT + MO2-notch3 + MO3-notch1a + MO3-notch3 + MO4-notch1a	standard conditions	Fig. 2 from Mizoguchi et al., 2011
hindbrain has number of Mauthner neuron, ameliorated	WT + MO3-notch1a + MO4-notch1a + MO5-appb	standard conditions	Fig. 7 from Banote et al., 2016

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Citations

Include unpublished citations

Banote, R.K., Edling, M., Eliassen, F., Kettunen, P., Zetterberg, H., Abramsson, A. (2016) β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner. Developmental Biology. 413(1):26-38
Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M. (2014) Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Developmental Biology. 391(2):196-206
Quillien, A., Moore, J.C., Shin, M., Siekmann, A.F., Smith, T., Pan, L., Moens, C.B., Parsons, M.J., Lawson, N.D. (2014) Distinct Notch signaling outputs pattern the developing arterial system. Development (Cambridge, England). 141:1544-52
Bugeon, L., Taylor, H.B., Progatzky, F., Lin, M.I., Ellis, C.D., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S.A., Chico, T.J., Zon, L., Lamb, J., and Dallman, M.J. (2011) The NOTCH pathway contributes to cell fate decisions in myelopoiesis. Haematologica. 96(12):1753-60
Mizoguchi, T., Togawa, S., Kawakami, K., and Itoh, M. (2011) Neuron and sensory epithelial cell fate is sequentially determined by notch signaling in zebrafish lateral line development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(43):15522-15530
Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyere, F., Cotelli, F., Kerjaschki, D., Noel, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., and Dewerchin, M. (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 30(9):1695-1702
Riedel-Kruse, I.H., Müller, C., and Oates, A.C. (2007) Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock. Science (New York, N.Y.). 317(5846):1911-1915
Tsutsumi, M., and Itoh, M. (2007) Novel transcript nort is a downstream target gene of the Notch signaling pathway in zebrafish. Gene expression patterns : GEP. 793):227-232
Holley, S.A., Jülich, D., Rauch, G.J., Geisler, R., and Nüsslein-Volhard, C. (2002) her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis. Development (Cambridge, England). 129(5):1175-1183

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