Gene

irx3a

ID
ZDB-GENE-991119-5
Name
iroquois homeobox 3a
Symbol
irx3a Nomenclature History
Previous Names
  • iro3 (1)
  • irx3
  • ziro3 (1)
  • hm:zehn0543
  • id:ibd3380 (1)
  • iro3-s1 (1)
  • iro3-s2 (1)
  • wu:fk88a03 (1)
  • zehn0543
  • zgc:109805
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in endocrine pancreas development and gastrulation. Predicted to localize to nucleus. Is expressed in several structures, including germ ring; hindbrain neural keel; nervous system; neural rod; and pancreatic system. Orthologous to human IRX3 (iroquois homeobox 3).
Genome Resources
Note
None
Expression
All Expression Data
41 figures from 24 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ragvin et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irx3a Human Ortholog
No data available
Associated With irx3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003893 Iroquois-class homeodomain protein
Domain IPR008422 Homeobox KN domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox KN domain Homeobox-like domain superfamily Iroquois-class homeodomain protein
UniProtKB:Q90Z68 454
UniProtKB:A7YYJ6 454
UniProtKB:A0A286Y9M4 450
UniProtKB:Q568V7 454
UniProtKB:Q9PVD8 420
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations