FIGURE

Fig. S6

ID

ZDB-FIG-100429-21

Publication

Gates et al., 2010 - The transcriptional repressor REST/NRSF modulates hedgehog signaling

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Fig. S6

Hh-induced downregulation of gli2a is not enhanced by co-injection of rest MO. Lateral view, head and hindbrain of embryos probed for either gli2a (A-D) or nkx2.2a (inserts A′-D′) for comparison. (A, B) gli2a expression in control and age matched rest morphants. C) Overexpression of shh results in decreased levels of gli2a and increased levels of nkx2.2a (C′). (D) Embryos injected with both rest mo and shh mRNA have dramatically enhanced nkx2.2a expression (D′), co-injection does not correspondingly downregulate gli2a expression (D).

Expression Data

Genes:	gli2a nkx2.2a
Fish:	WT WT + MO1-rest
Knockdown Reagent:	MO1-rest
Anatomical Terms:	forebrain hindbrain hindbrain neural tube ventral region midbrain
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 340(2), Gates, K.P., Mentzer, L., Karlstrom, R.O., and Sirotkin, H.I., The transcriptional repressor REST/NRSF modulates hedgehog signaling, 293-305, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.