FIGURE

Fig. S4

ID

ZDB-FIG-100429-19

Publication

Gates et al., 2010 - The transcriptional repressor REST/NRSF modulates hedgehog signaling

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Fig. S4

Rest knockdown enhances the effects of ectopic Hh signaling. Lateral views of embryos injected with control MO (Left column), shh mRNA (middle column) or shh mRNA in conjunction with rest MO (right column). (A-U) Embryos fixed around 24-28hpf and stained for Hh response genes . (V-X) Live 32hpf transgenic islet:eGFP embryos. (Middle column) Injection of shh mRNA results in dorsal expansion (B, E, H, K, N, W) or reduction (Q, T) in displayed markers. (Right column) Co-injection of rest MO alongside shh mRNA causes greater dorsal expansion (C, F, I, L,O, X) and a greater reduction in genes negatively regulated by Hh signaling (R, U).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 340(2), Gates, K.P., Mentzer, L., Karlstrom, R.O., and Sirotkin, H.I., The transcriptional repressor REST/NRSF modulates hedgehog signaling, 293-305, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.