Gene

nkx2.2a

ID
ZDB-GENE-980526-403
Name
NK2 homeobox 2a
Symbol
nkx2.2a Nomenclature History
Previous Names
  • nk2.2
  • nkx2-2
  • nkx2.2
  • id:ibd5090 (1)
  • wu:fc83b01
  • zgc:136536
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in endocrine pancreas development; nervous system development; and positive regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; digestive system; neural keel; neural rod; and neural tube. Orthologous to human NKX2-2 (NK2 homeobox 2).
Genome Resources
Note
None
Expression
All Expression Data
143 figures from 90 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nkx2.2a Human Ortholog
No data available
Associated With nkx2.2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily
UniProtKB:Q1RM24 269
UniProtKB:Q90481 269
UniProtKB:F1QNE4 273
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations