FIGURE

Fig. 5

ID

ZDB-FIG-090804-86

Publication

Nikolaou et al., 2009 - Lunatic fringe promotes the lateral inhibition of neurogenesis

Other Figures

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Fig. 5

Lfng and Notch1a in neuronal subtype choice. (A-D) Dorsal views of wild-type (A,C) and mib^ta52b homozygous mutant (B,D) embryos at 18 hpf showing notch1a (A,B) and deltaA (C,D) expression in the hindbrain. (E-L) Dorsal views of wild-type (E,I), notch1a^tp37 homozygous mutant (F,J) embryos, or control MO (G,K) and lfng^E1I1 MO (H,L) injected embryos at 26 hpf showing vsx1 (E-H) and gata3 (I-L) expression in the hindbrain that mark V2a and V2b interneurons (indicated by arrows), respectively. Expression of gata3 in nV and nVII branchiomotor neurons, indicated by the asterisks and arrowheads (I-L), respectively, is not affected in notch1a^tp37 embryos but increased following knockdown of lfng (insets in I-L). OTO, otocyst. Scale bars: 100 μm.

Expression Data

Genes:	dla gata3 notch1a vsx1
Fish:	WT mib1^ta52b/ta52b notch1a^tp37/tp37 WT + MO2-lfng
Knockdown Reagent:	MO2-lfng
Anatomical Terms:	CiD facial nerve motor nucleus hindbrain trigeminal motor nucleus VeLD
Stage Range:	14-19 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	notch1a^tp37/tp37 WT + MO2-lfng
Knockdown Reagent:	MO2-lfng
Observed In:	CiD VeLD
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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