Gene

gata3

ID

ZDB-GENE-990415-82

Name

GATA binding protein 3

Symbol

gata3 Nomenclature History

Previous Names

gta3 (1)
cb550 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic organ morphogenesis; generation of neurons; and tissue regeneration. Predicted to localize to nucleus. Used to study hypoparathyroidism-retardation-dysmorphism syndrome. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Is expressed in several structures, including digestive system; ectoderm; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human GATA3 (GATA binding protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

90 figures from 57 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb550 (29 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gata3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypoparathyroidism-deafness-renal disease syndrome	Alliance	Hypoparathyroidism, sensorineural deafness, and renal dysplasia	146255

Associated With gata3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
hypoparathyroidism-retardation-dysmorphism syndrome	gata3^b1075/b1075 (EKW)	standard conditions	Sheehan-Rooney et al., 2013
hypoparathyroidism-retardation-dysmorphism syndrome	gata3^b1075/b1075 (WIK)	standard conditions	Sheehan-Rooney et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000679	Zinc finger, GATA-type
Family	IPR016374	Transcription factor, GATA-2/3
Family	IPR039355	Transcription factor GATA
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type

Domain Details Per Protein

Protein	Length	Transcription factor GATA	Transcription factor, GATA-2/3	Zinc finger, GATA-type	Zinc finger, NHR/GATA-type
UniProtKB:A0A8M2BC31 InterPro	384
UniProtKB:Q91428 InterPro	438
UniProtKB:A0A8M2BC50 InterPro	403
UniProtKB:B3DGG5 InterPro	438
UniProtKB:A0A8M9Q5R9 InterPro	382
UniProtKB:A0A8M2BC08 InterPro	419