Gene

vsx1

ID
ZDB-GENE-990415-205
Name
visual system homeobox 1 homolog, chx10-like
Symbol
vsx1 Nomenclature History
Previous Names
  • etID309864.17 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables chromatin binding activity and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including negative regulation of axial mesodermal cell fate specification; nervous system development; and paraxial mesodermal cell fate specification. Predicted to be active in nucleus. Is expressed in blastomere; immature eye; nervous system; and neural tube. Human ortholog(s) of this gene implicated in corneal dystrophy; keratoconus; and posterior polymorphous corneal dystrophy 1. Orthologous to human VSX1 (visual system homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
37 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vsx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
keratoconus Alliance Keratoconus 1 148300
?Craniofacial anomalies and anterior segment dysgenesis syndrome 614195
Associated With vsx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR023339 CVC domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length CVC domain Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily
UniProtKB:F1QTW3 344
UniProtKB:F1QBH3 340
UniProtKB:O42250 344
UniProtKB:Q6PBV1 340
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vsx1 polyclonal Mouse
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations