FIGURE

Fig. 6

ID

ZDB-FIG-090224-33

Publication

Gribble et al., 2009 - Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression

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Fig. 6

sox4a is repressed by Tcf3 in spinal progenitors. (A,B) sox4a is weakly expressed in the spinal cord of wild-type embryos at 24 hpf and is ectopically expressed throughout the intermediate and ventral spinal cord of tcf3 morphants. (C) Overexpression of sox4a mRNA leads to ectopic HuC/D BrdU double-positive cells in medial progenitors (arrows). (D,E) sox3 is expressed in intermediate and ventral spinal progenitors of wild-type embryos at 24 hpf, and is drastically reduced in tcf3 morphants. (F) sox11a is expressed in both spinal progenitors and postmitotic neurons at 24 hpf. (G,H) sox4a overexpression does not affect the expression of dbx1a in spinal progenitors.

Expression Data

Genes:	dbx1a sox3 sox4a sox11a
Fish:	AB AB + MO2-tcf7l1a + MO3-tcf7l1b
Knockdown Reagents:	MO2-tcf7l1a MO3-tcf7l1b
Anatomical Terms:	spinal cord spinal cord neuroblast (sensu Vertebrata) spinal cord neuron
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO2-tcf7l1a + MO3-tcf7l1b
Knockdown Reagents:	MO2-tcf7l1a MO3-tcf7l1b
Observed In:	generation of neurons spinal cord neuroblast (sensu Vertebrata)
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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