ZFIN ID: ZDB-GENE-980526-333
Gene Name: SRY-box transcription factor 3
Gene Symbol: sox3    Nomenclature History

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Previous Names: id:ibd2036 (1), sb:cb493 (1), wu:fd02a08 (1), zgc:110279 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Contributes to DNA-binding transcription factor activity. Involved in several processes, including nervous system development; otic placode development; and otic placode formation. Predicted to localize to nucleus and transcription regulator complex. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural tube; and presumptive structure. Human ortholog(s) of this gene implicated in X-linked panhypopituitarism. Orthologous to human SOX3 (SRY-box transcription factor 3).
Genome Resources: Alliance (1),  Gene:30529 (1),  Ensembl(GRCz11):ENSDARG00000053569 (2)
GENE EXPRESSION
All Expression Data: 99 figures from 49 publications
Directly Submitted Expression Data: 4 figures (4 images) from Kudoh et al., 2001 [ibd2036]
  6 figures (32 images) from Thisse et al., 2001 [cb493]
  12 figures (43 images) from Rauch et al., 2003 [fc66h05]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Juvenile:Days 30-44 (30d-45d, 10 mm, adult fins/pigment)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh276 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh277 Point Mutation Unknown Unknown ENU
    sox3_unrecovered Point Mutation Unknown Unknown ENU
    whu101 Small Deletion Unknown Unknown CRISPR
    whu102 Small Deletion Unknown Unknown CRISPR
    x52 Small Deletion Unknown Frameshift, Premature Stop CRISPR
    x53 Indel Unknown Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-sox3 1
    CRISPR2-sox3 1
    MO1-sox3 N/A 1
    MO2-sox3 N/A 1
    MO3-sox3 N/A 6
    MO4-sox3 N/A 4
    MO5-sox2,sox3 N/A 3
    DISEASE ASSOCIATED WITH sox3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    X-linked panhypopituitarism Alliance Panhypopituitarism, X-linked 312000
    Mental retardation, X-linked, with isolated growth hormone deficiency 300123
    DISEASE ASSOCIATED WITH sox3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of DNA-binding transcription factor activity (more)
    Cellular Component nucleus (more)
    Molecular Function CONTRIBUTES_TO   DNA-binding transcription factor activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sox3-201 (1)    Ensembl 1764
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-Sox3 polyclonal Rabbit IHC 1
    Ab4-sox2 polyclonal IgG Goat WB R&D Systems
    5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:sox3) hsp70l sox3 Danio rerio 1 2
    Tg1(sox3-gata2a:EGFP) gata2asox3 EGFP Danio rerio 1 2
    Tg2(sox3-gata2a:EGFP) gata2asox3 EGFP Danio rerio 1 2
    Tg3(sox3-gata2a:EGFP) gata2asox3 EGFP Danio rerio 1 2
    Tg4(sox3-gata2a:EGFP) gata2asox3 EGFP Danio rerio 1 2
    Tg5(sox3-gata2a:EGFP) gata2asox3 EGFP Danio rerio 1 2
    Tg6(sox3-gata2a:EGFP) gata2asox3 EGFP Danio rerio 1 2
    Tg7(sox3-gata2a:EGFP) gata2asox3 EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    sox3 Contained in: [BAC] CH211-143L19 (1), CH211-285J6 (1)
    sox3 Encodes: [EST] cb493 (1) (order this), fc66h05 (1) (order this), fd02a08 (1), ibd2036 (1)
    [cDNA] MGC:110279 (1), MGC:174245 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001811 (1) 1781 nt
    Genomic GenBank:BX088596 142350 nt
    Select Tool
    Polypeptide UniProtKB:A9JSZ3 (1) 300 aa
    Sequence Information (all 29)
    ORTHOLOGY for sox3 ( Chr: 14 )
    CITATIONS (124)