Gene

sox11a

ID

ZDB-GENE-980526-395

Name

SRY-box transcription factor 11a

Symbol

sox11a Nomenclature History

Previous Names

cb237 (1)
etID309973.17 (1)
id:ibd2104 (1)
wu:fb16g02 (1)
zgc:136533

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in brain development; camera-type eye development; and negative regulation of smoothened signaling pathway. Predicted to localize to nucleus and transcription regulator complex. Is expressed in several structures, including mesoderm; nervous system; neural keel; neural rod; and somite. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 27. Orthologous to human SOX11 (SRY-box transcription factor 11).

Genome Resources

Note

None

Expression

All Expression Data

33 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Tsurusaki et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sox11a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Coffin-Siris syndrome 9	Alliance	Coffin-Siris syndrome 9	615866

Associated With sox11a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Family	IPR017386	Transcription factor SOX-12/11/4
Family	IPR029551	Transcription factor SOX-11
Homologous_superfamily	IPR036910	High mobility group box domain superfamily